{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:47:57Z","timestamp":1767649677657,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["P60-AR-48098","R01-AR-055287"],"award-info":[{"award-number":["P60-AR-48098","R01-AR-055287"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Health\u2010related utility measures overall health status and quality of life and is commonly incorporated into cost\u2010effectiveness analyses. This study investigates whether attainment of federal physical activity guidelines translates into better health\u2010related utility in adults with or at risk for knee osteoarthritis (OA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional data from 1,908 adults with or at risk for knee OA participating in the accelerometer ancillary study of the Osteoarthritis Initiative were assessed. Physical activity was measured using 7 days of accelerometer monitoring and was classified as 1) meeting guidelines (\u2265150 bouted moderate\u2010to\u2010vigorous [MV] minutes per week); 2) insufficiently active (\u22651 MV bout[s] per week but below guidelines); or 3) inactive (zero MV bouts per week). A Short Form 6D health\u2010related utility score was derived from patient\u2010reported health status. Relationship of physical activity levels to median health\u2010related utility adjusted for socioeconomic and health factors was tested using quantile regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 13% of participants met physical activity guidelines, and 45% were inactive. Relative to the inactive group, median health\u2010related utility scores were significantly greater for the meeting guidelines group (0.063; 95% confidence interval [95% CI] 0.055, 0.071) and the insufficiently active group (0.059; 95% CI 0.054, 0.064). These differences showed a statistically significant linear trend and strong cross\u2010sectional relationship with physical activity level even after adjusting for socioeconomic and health factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a significant positive relationship between physical activity level and health\u2010related utility. Interventions that encourage adults, including persons with knee OA, to increase physical activity even if recommended levels are not attained may improve their quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22262","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T15:04:50Z","timestamp":1386687890000},"page":"1041-1047","source":"Crossref","is-referenced-by-count":22,"title":["Relationship of Meeting Physical Activity Guidelines With Health\u2010Related Utility"],"prefix":"10.1002","volume":"66","author":[{"given":"Kai","family":"Sun","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Song","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungwha","family":"Lee","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowland W.","family":"Chang","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Brown University School of Medicine Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Ehrlich\u2010Jones","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent C.","family":"Kwoh","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry M.","family":"Manheim","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Semanik","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Sharma","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Woong","family":"Sohn","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy D.","family":"Dunlop","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0459"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000245568.69434.1a"},{"key":"e_1_2_6_5_1","first-page":"1851","article-title":"The impact of functional status and change in functional status on mortality over 18 years among persons with rheumatoid arthritis","volume":"29","author":"Yelin E","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_1","first-page":"8","article-title":"Cost of musculoskeletal diseases: impact of work disability and functional decline","volume":"68","author":"Yelin E","year":"2003","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)45:5<439::AID-ART363>3.0.CO;2-M"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(96)00060-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe038129"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa020614"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23239"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20968"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.19.2309"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540250033028"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e318155a7fe"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2008.142927"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11420"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22906"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3181877d1a"},{"volume-title":"2008 physical activity guidelines for Americans","author":"Department of Health and Human Services","key":"e_1_2_6_22_1"},{"key":"e_1_2_6_23_1","unstructured":"NevittM Felson D Lester G. The Osteoarthritis Initiative protocol for the cohort study.2006. URL:http:\/\/oai.epi\u2010ucsf.org\/datarelease\/docs\/StudyDesignProtocol.pdf."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0603-z"},{"key":"e_1_2_6_25_1","unstructured":"Osteoarthritis Initiative. Overview and description of central image assessments.2011. URL:http:\/\/oai.epi\u2010ucsf.org\/datarelease\/docs\/ImageAssessments\/ImageAssessmentDataOverview.pdf."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000135827.18610.0d"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(01)00130-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3181c162a2"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200208000-00021"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000079078.62035.EC"},{"key":"e_1_2_6_31_1","first-page":"1637","article-title":"Reliability of accelerometry\u2010 based activity monitors: a generalizability study","volume":"36","author":"Welk GJ","year":"2004","journal-title":"Med Sci Sports Exerc"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24007"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181cfc9da"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20305"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31815a51b3"},{"volume-title":"2008 physical activity guidelines for Americans","year":"2008","author":"Physical Activity Guidelines Committee","key":"e_1_2_6_36_1"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199601000-00006"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.2.131"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30562"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1388"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.01.015"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.19.2137"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290054029"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021067"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27760"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21639"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21754"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21803"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22262","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:51:45Z","timestamp":1759416705000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/acr.22262"],"URL":"https:\/\/doi.org\/10.1002\/acr.22262","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2014,6,26]]}}}