{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:30:58Z","timestamp":1773923458928,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-NIAMS R21AR057924"],"award-info":[{"award-number":["NIH-NIAMS R21AR057924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Observational studies suggest that hydroxychloroquine (HCQ) may reduce the risk of developing diabetes mellitus in patients with rheumatoid arthritis (RA). We examined the effect of HCQ on insulin resistance in subjects without diabetes mellitus with stable RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three RA subjects not currently using HCQ completed a 16\u2010week, double\u2010blind crossover study. Subjects were randomly allocated to receive HCQ (6.5 mg\/kg\/day) or placebo for the first 8 weeks, followed by crossover to the other arm for the final 8 weeks. Subjects underwent oral glucose tolerance testing and fasting lipid measurements at baseline, 8 weeks, and 16 weeks. The change \u00b1 SD from baseline in insulin sensitivity index (ISI), homeostatic model assessment for insulin resistance (HOMA\u2010IR), and lipid parameters were compared between placebo and HCQ using linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean patient age was 56 years, with 96% women, and the median body mass index was 26.0 kg\/m<jats:sup>2<\/jats:sup>. After 8 weeks of HCQ, the mean \u00b1 SD ISI increase was 0.4 \u00b1 2.9 compared with a small increase during placebo of 0.14 \u00b1 3.1 (adjusted <jats:italic>P<\/jats:italic> = 0.785), and the mean \u00b1 SD HOMA\u2010IR decrease was 0.3 \u00b1 1.5 during HCQ versus a decrease of 0.42 \u00b1 1.4 during placebo (adjusted <jats:italic>P<\/jats:italic> = 0.308). Small decreases in total cholesterol (12.7 mg\/dl) and low\u2010density lipoprotein (LDL) cholesterol (12.4 mg\/dl) were observed during the HCQ treatment periods (both adjusted <jats:italic>P<\/jats:italic> &lt; 0.05 compared to placebo).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HCQ use for 8 weeks in patients without diabetes mellitus with stable RA produced no significant change in insulin resistance. We observed small and statistically significant improvements in total and LDL cholesterol during HCQ treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22285","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T14:09:27Z","timestamp":1390831767000},"page":"1246-1251","source":"Crossref","is-referenced-by-count":64,"title":["Effect of Hydroxychloroquine on Insulin Sensitivity and Lipid Parameters in Rheumatoid Arthritis Patients Without Diabetes Mellitus: A Randomized, Blinded Crossover Trial"],"prefix":"10.1002","volume":"66","author":[{"given":"Daniel H.","family":"Solomon","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Garg","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derrick J.","family":"Todd","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emileigh","family":"Mercer","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabatha","family":"Norton","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Massarotti","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22157"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-063"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/y98-146"},{"key":"e_1_2_7_6_1","first-page":"195","article-title":"Hypoglycemia induced by hydroxychloroquine in a type II diabetic treated for polyarthritis","volume":"26","author":"Shojania K","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-9-678"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(01)00325-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.2.187"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.878"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3868"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90151-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124743-199702000-00002"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22285","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:57:12Z","timestamp":1759420632000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,28]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/acr.22285"],"URL":"https:\/\/doi.org\/10.1002\/acr.22285","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,28]]}}}