{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:28Z","timestamp":1760189368481,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIAMS-CORT"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Systemic sclerosis (SSC; scleroderma)\u2013associated pulmonary arterial hypertension (PAH) is a major cause of mortality in SSc patients and represents an important diagnostic and therapeutic target. Our aims were to evaluate the relationship between echocardiogram\u2010derived right\u2010sided heart hemodynamics and gold standard right\u2010sided heart catheterization (RHC) measurements in a scleroderma population and to investigate whether this relationship is modified by a subset of pulmonary hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed RHC and echocardiography on the same day, with pulmonary function testing in 21 consecutive subjects with scleroderma and precapillary pulmonary hypertension (mean \u00b1 SD age 57 \u00b1 10 years, 81% women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RHC measures, including pulmonary arterial systolic and mean pressure and pulmonary vascular resistance (PVR), correlated strongly with echocardiogram\u2010derived data. RHC\u2010derived PVR was negatively associated with right ventricular (RV) systolic performance, as measured by tricuspid annular plane systolic excursion (TAPSE; rho = \u22120.70, <jats:italic>P<\/jats:italic> &lt; 0.001), tissue Doppler tricuspid s\u2032 velocity (rho = \u22120.68, <jats:italic>P<\/jats:italic> = 0.002), and RV fractional area change (rho = \u22120.78, <jats:italic>P<\/jats:italic> &lt; 0.001). Correlations with TAPSE and s\u2032 velocity were strengthened when forced vital capacity %\/diffusing capacity of the lung for carbon monoxide % \u22651.6 was used to identify pure PAH phenotypes in SSc. Bland\u2010Altman analyses demonstrated strong agreement between RHC and echocardiogram\u2010derived hemodynamic measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that echocardiography may play a clinical role in identifying pulmonary hypertension and RV dysfunction noninvasively, particularly in a subset of SSc patients stratified by pulmonary function testing. This method may establish specific disease phenotypes with differential cardiovascular impact and prove useful as a marker of disease progression\/risk stratification in SSC patients that warrants further investigation in larger cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22307","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T17:12:44Z","timestamp":1392138764000},"page":"1386-1394","source":"Crossref","is-referenced-by-count":15,"title":["Relation of Novel Echocardiographic Measures to Invasive Hemodynamic Assessment in Scleroderma\u2010Associated Pulmonary Arterial Hypertension"],"prefix":"10.1002","volume":"66","author":[{"given":"Deepa M.","family":"Gopal","sequence":"first","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Doldt","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Finch","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Simms","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison W.","family":"Farber","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noyan","family":"Gokce","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-1-200401060-00010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1088"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090661"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh067"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.2.239"},{"key":"e_1_2_7_10_1","first-page":"458","article-title":"Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: comparison of noninvasive tests with results of right\u2010heart catheterization","volume":"35","author":"Hsu VM","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-547OC"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.051"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.11.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02973-X"},{"key":"e_1_2_7_17_1","first-page":"383","volume-title":"Braunwald's heart disease: a textbook of cardiovascular medicine","author":"Braunwald E","year":"2012"},{"key":"e_1_2_7_18_1","article-title":"Evidence\u2010based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study","author":"Coghlan JG","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350709"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20693"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10775"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24267"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21538"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01467.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110512"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00305.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2473"}],"container-title":["Arthritis Care &amp; 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