{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:31:23Z","timestamp":1783535483081,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare the efficacy and safety of rituximab (RTX) as a function of patient age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all rheumatoid arthritis patients in the AutoImmunity and Rituximab registry with a 2\u2010year followup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,709 patients, 191 were age \u226575 years, 417 were ages 65\u201374 years, 907 were ages 50\u201364 years, and 194 were age &lt;50 years. At baseline, the elderly and very elderly patients presented with longer disease duration, a higher incidence of erythrocyte sedimentation rate and C\u2010reactive protein level, a lower incidence of previous tumor necrosis factor \u03b1 (TNF\u03b1) therapy, and a smaller number of previously used TNF\u03b1 agents. Disease activity, rheumatoid factor (RF), or anti\u2013cyclic citrullinated peptide (anti\u2010CCP) antibodies and corticosteroid therapy were not statistically different among the groups. At 24 months, no significant difference was shown among the groups for RTX discontinuation rates (36.1% if age &lt;50 years, 32.6% if ages 50\u201364 years, 34.5% if ages 65\u201374 years, and 32.5% if age &gt;75 years). The reasons for discontinuation (inefficacy, adverse events) were the same in all 4 groups. Infections were more common in the elderly. Patients ages 65\u201375 years were more likely to be good responders than nonresponders at 1 year of followup than patients age \u226575 years (odds ratio 3.81, 95% confidence interval 1.14\u201312.79) after adjustment on disease duration, RF\/anti\u2010CCP positivity, corticosteroids, anti\u2010TNF use, and baseline Disease Activity Score in 28 joints (DAS28). After the sixth month, the decrease in DAS28 score was less marked in the population age &gt;75 years than in the group age &lt;50 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy and safety of RTX is affected by age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22314","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T09:44:49Z","timestamp":1392889489000},"page":"1289-1295","source":"Crossref","is-referenced-by-count":46,"title":["Efficacy and Safety of Rituximab in Elderly Patients With Rheumatoid Arthritis Enrolled in a French Society of Rheumatology Registry"],"prefix":"10.1002","volume":"66","author":[{"given":"Sarah","family":"Payet","sequence":"first","affiliation":[{"name":"Clermont\u2010Ferrand Teaching Hospital Clermont\u2010Ferrand 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