{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:32:17Z","timestamp":1761129137787,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the frequency of and factors associated with early tumor necrosis factor \u03b1 (TNF\u03b1) antagonist therapy in everyday clinical practice in patients with suspected axial spondyloarthropathy (SpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the prospective observational study in the French Devenir des Spondylarthropathies Indiff\u00e9renci\u00e9es R\u00e9centes (DESIR; Outcome of Recent Undifferentiated Spondylarthropathies) cohort of 708 patients with recent\u2010onset (&lt;3 years) inflammatory back pain (IBP) suggesting axial SpA. TNF\u03b1 antagonist use was recorded at months 6 and 12 and factors independently associated with TNF\u03b1 antagonist therapy were identified by multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 708 patients (mean age 33.8 years, 46.2% men), 166 (23.4%) patients received TNF\u03b1 antagonist therapy by month 12, including 120 (73.6%) patients who fulfilled Assessment of SpondyloArthritis international Society (ASAS) axial criteria and 157 (94.6%) who fulfilled at least 1 SpA criteria set; 109 (65.6%) had no sacroiliitis. Factors independently associated with early TNF\u03b1 antagonist therapy were high Ankylosing Spondylitis Disease Activity Score using the C\u2010reactive protein level (odds ratio [OR]<jats:sub>1\u2010point increase<\/jats:sub> 1.60, 95% confidence interval [95% CI] 1.25\u20132.03, <jats:italic>P<\/jats:italic> &lt; 0.001), high physician's global disease activity score (OR 1.37, 95% CI 1.21\u20131.54, <jats:italic>P<\/jats:italic> &lt; 0.001), ASAS nonsteroidal antiinflammatory drug score &gt;50 (OR 1.88, 95% CI 1.24\u20132.87, <jats:italic>P<\/jats:italic> = 0.003), current or past disease\u2010modifying antirheumatic drug use (OR 2.09, 95% CI 1.22\u20133.59, <jats:italic>P<\/jats:italic> = 0.008), systemic corticosteroid use (OR 2.48, 95% CI 1.43\u20134.34, <jats:italic>P<\/jats:italic> = 0.002), and mild to severe radiographic hip abnormalities (OR 9.43, 95% CI 2.11\u201342.09, <jats:italic>P<\/jats:italic> = 0.003). After adjustment on these factors, Achilles enthesis hypervascularization by power Doppler and number of work days missed were associated with TNF\u03b1 antagonist therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the DESIR cohort, approximately one\u2010fourth of patients with recent IBP suggestive of axial SpA were under anti\u2010TNF\u03b1 therapy after 1 year of followup. All factors associated with this early initiation reflected higher disease activity, refractoriness, or severity, which suggests compliance of French rheumatologists with current treatment guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22330","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T23:16:03Z","timestamp":1395702963000},"page":"1395-1402","source":"Crossref","is-referenced-by-count":10,"title":["Early Tumor Necrosis Factor \u03b1 Antagonist Therapy in Everyday Practice for Inflammatory Back Pain Suggesting Axial Spondyloarthritis: Results From a Prospective Multicenter French Cohort"],"prefix":"10.1002","volume":"66","author":[{"given":"Florence","family":"Canou\u00ef\u2010Poitrine","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil and APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Poulain","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Molto","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Le Thuaut","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil and APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Lafon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France, and Ecole Nationale de la Statistique et de l'Analyse de l'Information Bruz France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Farrenq","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Ferkal","sequence":"additional","affiliation":[{"name":"INSERM, Centre d'Investigation Clinique 006 Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Le Corvoisier","sequence":"additional","affiliation":[{"name":"INSERM, Centre d'Investigation Clinique 006 Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"Ghaleh","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Bastuji\u2010Garin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil and APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fautrel","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re, Universit\u00e9 Paris 6 \u2010 Pierre et Marie Curie Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Claudepierre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil and APHP, H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.040758"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151563"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108217"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.10.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.042630"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.147744"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835257c5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep422"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.01.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03270510035017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21619"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133488"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.1.66"},{"key":"e_1_2_7_17_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094870"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"key":"e_1_2_7_20_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)00227-H"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330712"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.7.655"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020503"},{"key":"e_1_2_7_25_1","first-page":"85","article-title":"Criteria of the classification of spondylarthropathies","volume":"57","author":"Amor B","year":"1990","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.011130"},{"key":"e_1_2_7_28_1","first-page":"1","article-title":"Non\u2010radiographic axial spondyloarthritis: what is it?","volume":"32","author":"Fianyo E","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10812"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:41:33Z","timestamp":1759416093000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,26]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/acr.22330"],"URL":"https:\/\/doi.org\/10.1002\/acr.22330","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2014,8,26]]}}}