{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:24Z","timestamp":1788871524918,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR056664"],"award-info":[{"award-number":["R01AR056664"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the responsiveness and reader time of a novel semiautomated tool to detect knee cartilage loss over 2 years in subjects with knee osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 122 subjects from the Osteoarthritis Initiative progression cohort were selected. A reader used the software method to segment cartilage on double\u2010echo steady\u2010state sequence scans in the medial compartment of the femur from the baseline and 24\u2010month visits. Change in cartilage volume (\u0394V) was measured at a fixed weight\u2010bearing (WB) location with respect to the 3\u2010dimensional coordinate system based on cylindrical coordinates. Change was measured for 5 regions of varying WB surface area centered on the fixed point. The average change (\u0394V), the SD of \u0394V, and the standardized response mean (SRM) are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SRM was \u22120.52 for the largest region and decreased in magnitude as smaller regions of cartilage were probed. The average evaluation time was &lt;20 minutes per knee compartment, split approximately evenly between a technician and a trained reader.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results establish that measurement of cartilage loss in a local region can be done efficiently and that the resultant measures are responsive to loss of cartilage over time. The coordinate system can potentially be used to objectively examine and establish a consistent location for all knees that is most responsive to change in cartilage volume. This technique can provide rapidly an objective quantitative measure of cartilage loss and could substantially reduce study costs for large trials and data sets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.22332","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T23:16:16Z","timestamp":1395702976000},"page":"1560-1565","source":"Crossref","is-referenced-by-count":20,"title":["Local Area Cartilage Segmentation: A Semiautomated Novel Method of Measuring Cartilage Loss in Knee Osteoarthritis"],"prefix":"10.1002","volume":"66","author":[{"given":"Jeffrey","family":"Duryea","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Iranpour\u2010Boroujeni","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E.","family":"Collins","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School, and Boston University School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Case","family":"Vanwynngaarden","sequence":"additional","affiliation":[{"name":"Northern Lights Regional Health Care Centre Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Losina","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School, and Boston University School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Russell","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ratzlaff","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066183"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.198.3.8628883"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199903)41:3<529::AID-MRM15>3.0.CO;2-Z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21348"},{"key":"e_1_2_8_7_1","first-page":"327","article-title":"Automatic segmentation of the articular cartilage in knee MRI using a hierarchical multi\u2010class classification scheme","volume":"8","author":"Folkesson J","year":"2005","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.09.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2272"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.12.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.082107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20148"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.03.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24613"}],"container-title":["Arthritis Care &amp; 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