{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:29:58Z","timestamp":1792092598158,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23-AR-053202"],"award-info":[{"award-number":["K23-AR-053202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the influence of ethnicity on self\u2010reported health\u2010related quality of life (HRQOL) in the Canadian childhood\u2010onset systemic lupus erythematosus (cSLE) population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with cSLE at 4 pediatric centers were consecutively enrolled. Sociodemographics and multiple disease activity measures were collected. The Child Health Questionnaire (CHQ) was administered and analyzed by ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 213 cSLE patients, and complete data from 196 patients with the following ethnicities were analyzed: white (33%), Asian (32%), South Asian (16%), African American (11%), Latino\/Hispanic (5%), and Aboriginal (4%). Compared to healthy children, cSLE patients rated their HRQOL significantly more poorly in 9 of 10 individual domains, and in 4 of 10 domains when compared to a cohort of juvenile arthritis patients. Within the cSLE cohort, CHQ scores were lower in 5 of 10 domains in white patients versus nonwhite ethnicities (<jats:italic>P<\/jats:italic> &lt; 0.05 for each). Physical summary scores were lower for white patients compared to the other ethnicities aggregated together (mean \u00b1 SD 46.0 \u00b1 11.9 versus 50.4 \u00b1 10.1; <jats:italic>P<\/jats:italic> = 0.009); however, psychosocial summary scores were similar among the groups (mean \u00b1 SD 40.5 \u00b1 14.6 versus 42.8 \u00b1 12.7; <jats:italic>P<\/jats:italic> = 0.26). Disease activity measures, including the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus Activity Measure, Revised, and physician global visual analog scale, were similar across ethnicities. However, patient\u2010reported Systemic Lupus Erythematosus Activity Questionnaire symptom scores were greater in patients of white ethnicity compared to those of Asian ethnicity (mean \u00b1 SD 8.2 \u00b1 5.8 versus 4.5 \u00b1 4.7; <jats:italic>P<\/jats:italic> = 0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The self\u2010 and parent\u2010reported health status of Canadian cSLE patients differed across ethnicities, with white patients reporting lower HRQOL despite similar and overall low disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22363","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T13:54:37Z","timestamp":1399902877000},"page":"1767-1774","source":"Crossref","is-referenced-by-count":25,"title":["Association of Health\u2010Related Quality of Life in Childhood\u2010Onset Systemic Lupus Erythematosus With Ethnicity: Results From a Multiethnic Multicenter Canadian Cohort"],"prefix":"10.1002","volume":"66","author":[{"given":"Deborah M.","family":"Levy","sequence":"first","affiliation":[{"name":"Hospital for Sick Children and University of Toronto Toronto, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Peschken","sequence":"additional","affiliation":[{"name":"University of Manitoba Winnipeg, Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori B.","family":"Tucker","sequence":"additional","affiliation":[{"name":"BC Children's Hospital and University of British Columbia Vancouver, British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Ch\u00e9deville","sequence":"additional","affiliation":[{"name":"The Montreal Children's Hospital and McGill University Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Huber","sequence":"additional","affiliation":[{"name":"IWK Health Centre and Dalhousie University Halifax, Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Pope","sequence":"additional","affiliation":[{"name":"University of Western Ontario London, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Network for Improved Outcomes in SLE (CaNIOS) 1000 Faces Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl D.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children and University of Toronto Toronto, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.01.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081164"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2075oa"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20412"},{"key":"e_1_2_6_6_1","volume-title":"J Rheumatol 2009","author":"Hiraki LT"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016345032580"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307087875"},{"key":"e_1_2_6_9_1","first-page":"1650","article-title":"Gender and ethnic origin have no effect on longterm outcome of childhood\u2010onset systemic lupus erythematosus","volume":"31","author":"Miettunen PM","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22641"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)12:4<256::AID-ART4>3.0.CO;2-G"},{"key":"e_1_2_6_12_1","first-page":"1414","article-title":"A prospective study of factors affecting quality of life in systemic lupus erythematosus","volume":"27","author":"Thumboo J","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311412097"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309345770"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080912"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21779"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_18_1","unstructured":"Statistics Canada. 2001 census dictionary. 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