{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:48:51Z","timestamp":1759452531254,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Research Board and National Council for Nursing and Midwifery (JCSNM)","award":["JCSNM\/2006\/5"],"award-info":[{"award-number":["JCSNM\/2006\/5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the relationship between fatigue and the American College of Rheumatology (ACR) core set outcomes in patients with inflammatory arthritis (IA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective longitudinal study evaluated fatigue in patients with active IA commencing tumor necrosis factor (TNF) inhibitor therapy. Fatigue was assessed using the multidimensional assessment of fatigue scale and the ACR core set (swollen and tender joint counts, pain, global health score, Health Assessment Questionnaire [HAQ] disability index [DI], and C\u2010reactive protein level) was used for standard assessment of disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assessments at baseline, 3 months, and 6 months were completed by 125, 92, and 82 patients, respectively. Fatigue and disease activity improved significantly within the first 3 months, with fatigue improving by 29% (F[2, 118] = 17.14, <jats:italic>P<\/jats:italic> &lt; 0.001; repeated\u2010measures analysis of variance). Using multiple regression, the amount of fatigue explained by the core outcomes differed at each time point: 28% at baseline (<jats:italic>P<\/jats:italic> &lt; 0.001; significant predictors were the HAQ DI, global health, and C\u2010reactive protein level), 37% at 3 months (<jats:italic>P<\/jats:italic> &lt; 0.001; significant predictors were pain and tender joint count), and 46% at 6 months (<jats:italic>P<\/jats:italic> &lt; 0.001; significant predictor was global health). Regression modelling using the fatigue change score at 3 months explained 17% of fatigue change (<jats:italic>P<\/jats:italic> &lt; 0.012; significant predictors were HAQ DI and global health).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fatigue, which improved following treatment with TNF inhibitors, was poorly and inconsistently explained through the core set outcomes. Further, fatigue was least accounted for when the disease was most active, highlighting the need for further research into alternate explanations. These findings suggest further exploration of contributing variables and mechanisms in order to develop targeted symptom management of fatigue in IA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22387","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T11:27:43Z","timestamp":1403695663000},"page":"1597-1603","source":"Crossref","is-referenced-by-count":10,"title":["How Much Is Fatigue Explained by Standard Clinical Characteristics of Disease Activity in Patients With Inflammatory Arthritis? A Longitudinal Study"],"prefix":"10.1002","volume":"66","author":[{"given":"Patricia","family":"Minnock","sequence":"first","affiliation":[{"name":"Our Lady's Hospice &amp; Care Services Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"McKee","sequence":"additional","affiliation":[{"name":"Trinity College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Bresnihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"Our Lady's Hospice &amp; Care Services, St Vincent's University Hospital, and University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas J.","family":"Veale","sequence":"additional","affiliation":[{"name":"Our Lady's Hospice &amp; Care Services, St Vincent's University Hospital, and University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken399"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq282"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30129"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.034165"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790030203"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790030307"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.1991.tb01803.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-199303000-00006"},{"key":"e_1_2_6_11_1","first-page":"639","article-title":"Comparison of self\u2010reported fatigue in rheumatoid arthritis and controls","volume":"22","author":"Belza BL","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_1","first-page":"868","article-title":"Outcomes from the Patient Perspective Workshop at OMERACT 6","volume":"30","author":"Kirwan J","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","first-page":"2262","article-title":"Outcome measures in psoriatic arthritis","volume":"32","author":"Gladman DD","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_14_1","first-page":"2250","article-title":"Incorporating the patient perspective into outcome assessment in rheumatoid arthritis: progress at OMERACT 7","volume":"32","author":"Kirwan JR","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_15_1","first-page":"1174","article-title":"Patient perspective: fatigue as a recommended patient centered outcome measure in rheumatoid arthritis","volume":"34","author":"Kirwan JR","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21209"},{"key":"e_1_2_6_17_1","first-page":"2115","article-title":"Fatigue, rheumatoid arthritis, and anti\u2010tumor necrosis factor therapy: an investigation in 24,831 patients","volume":"31","author":"Wolfe F","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2012.709878"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21450"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21949"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100179"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel021"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1887-y"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker162"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker219"},{"key":"e_1_2_6_26_1","first-page":"1407","article-title":"The prevalence and meaning of fatigue in rheumatic disease","volume":"23","author":"Wolfe F","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090561"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(73)90035-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.12.793"},{"key":"e_1_2_6_32_1","unstructured":"University of Washington School of Nursing. Multidimensional assessment of fatigue (MAF) user's guide. URL:http:\/\/www.son.washington.edu\/research\/maf\/users\u2010guide.asp."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22611"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1547-5069.2007.00161.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360601"},{"issue":"39","key":"e_1_2_6_36_1","first-page":"S14","article-title":"The Health Assessment Questionnaire (HAQ)","volume":"23","author":"Bruce B","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_37_1","unstructured":"Disease Activity Score in rheumatoid arthritis. URL:http:\/\/www.das\u2010score.nl\/das28\/en\/."},{"issue":"39","key":"e_1_2_6_38_1","first-page":"S93","article-title":"The Disease Activity Score and the EULAR response criteria","volume":"23","author":"Fransen J","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep287"},{"key":"e_1_2_6_40_1","first-page":"401","article-title":"Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis","volume":"28","author":"Minnock P","year":"2010","journal-title":"Clin Exp Rheumatol"},{"volume-title":"Statistical power analysis for the behavioral sciences","year":"1988","author":"Cohen J","key":"e_1_2_6_41_1"},{"volume-title":"Design and analysis: a researcher's handbook","year":"2004","author":"Keppel G","key":"e_1_2_6_42_1"},{"volume-title":"Statistical methods for psychology","year":"2007","author":"Howell DC","key":"e_1_2_6_43_1"},{"volume-title":"SPSS 16 made simple","year":"2009","author":"Kinnear PR","key":"e_1_2_6_44_1"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144691"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460816.2.5.439"},{"key":"e_1_2_6_47_1","first-page":"S471","article-title":"Pain outcome and fatigue levels reported by women with established rheumatoid arthritis","volume":"50","author":"Minnock P","year":"2004","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091454"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep423"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq209"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22387","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:24:49Z","timestamp":1759422289000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/acr.22387"],"URL":"https:\/\/doi.org\/10.1002\/acr.22387","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}