{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:13:35Z","timestamp":1784121215551,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the LG Life Sciences","award":["IIS-2013-16"],"award-info":[{"award-number":["IIS-2013-16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Allopurinol\u2010induced severe cutaneous adverse reactions (SCARs) are relatively rare but cause high rates of morbidity and mortality. Studies have shown that the HLA\u2013B5801 allele and renal impairment are strongly associated with SCARs. Recent American College of Rheumatology guidelines recommend that, prior to treatment with allopurinol, the HLA\u2013B5801 genotype of gout patients at high risk for SCARs, including Korean patients with chronic renal insufficiency, should be determined. However, whether such genotyping is cost\u2010effective is unknown. This study evaluated the cost\u2010effectiveness of HLA\u2013B5801 genotyping for the treatment of gout in patients with chronic renal insufficiency in Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A decision analytical model over a time period of 12 months was employed to compare the cost and outcomes of treatment informed by HLA\u2013B5801 genotyping with that of a conventional treatment strategy using a hypothetical cohort of gout patients with chronic renal insufficiency. Direct medical costs were obtained from real patients with SCARs from 2 tertiary hospitals. Outcomes were measured as a total expected cost and an incremental cost\u2010effectiveness ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the base model, the total expected cost and probability of continuation of gout treatment without SCARs for the conventional and HLA\u2013B5801 screening strategies were $1,193 and 97.8% and $1,055 and 100%, respectively. The results were robust according to sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our model suggests that gout treatment informed by HLA\u2013B5801 genotyping is less costly and more effective than treatment without genotyping, and HLA\u2013B5801 genotyping could considerably reduce the occurrence of allopurinol\u2010induced SCARs and related deaths.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.22409","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T14:06:12Z","timestamp":1405951572000},"page":"280-287","source":"Crossref","is-referenced-by-count":64,"title":["Cost\u2010Effectiveness Analysis of HLA\u2013B5801 Genotyping in the Treatment of Gout Patients With Chronic Renal Insufficiency in Korea"],"prefix":"10.1002","volume":"67","author":[{"given":"Dong\u2010Jin","family":"Park","sequence":"first","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hyoun","family":"Kang","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Wen","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School &amp; Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332404"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290111"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr060"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90743-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31829372e6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.10.981"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409500102"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/428486a"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282370c5f"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2005.00386.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328330a3b8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24209"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2010.30.6.685"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34488"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21817"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21773"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30119"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.036"},{"key":"e_1_2_6_21_1","first-page":"384","article-title":"Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?","volume":"49","author":"Lee HY","year":"2008","journal-title":"Singapore Med J"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700317"},{"key":"e_1_2_6_23_1","first-page":"656","article-title":"Allopurinol\u2010induced DRESS syndrome","volume":"7","author":"Markel A","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.12.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3806"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.09.009"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050046"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07873-X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013297"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f3ef9c"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-118"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4733.2003.00234.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110092"}],"container-title":["Arthritis Care &amp; 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