{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:31:15Z","timestamp":1792690275622,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23AR059749"],"award-info":[{"award-number":["1K23AR059749"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA) for use in clinical practice and research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using modified Delphi consensus techniques, 10 items were selected by participants in the international pediatric rheumatology listserv, the Childhood Arthritis and Rheumatology Research Alliance, and the listserv for the pediatric section of the American College of Rheumatology. Validation was performed in a retrospective multicenter cohort of 244 children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 106 physicians representing 14 countries completed the initial questionnaire. Completion rates for the subsequent questionnaires were 84%, 75%, and 77% of the original respondents. Ten items exceeded 80% consensus: arthritis, enthesitis, patient pain assessment, inflammatory markers, morning stiffness, clinical sacroiliitis, uveitis, back mobility, and patient and physician assessments of disease activity. After item analysis, 2 items were eliminated (patient and physician assessments of disease activity). Factor analysis identified 3 primary domains that explained 58% of the variance: peripheral disease, axial disease, and uveitis. The Cronbach's \u03b1 coefficient was 0.66. The JSpADA had high or moderate correlations with the Juvenile Arthritis Disease Activity Score (r = 0.81), patient and physician assessments of disease activity (r = 0.70 and r = 0.66, respectively), and the Childhood Health Assessment Questionnaire (r = 0.56). The JSpADA discriminated well between subjects with active versus inactive disease (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and was responsive to improvement or worsening in disease activity over time (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using international input and consensus formation techniques, we developed and validated the first disease activity assessment for juvenile spondyloarthritis. Future studies should validate the JSpADA in a prospective multicenter cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.22411","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T14:06:17Z","timestamp":1405951577000},"page":"1775-1782","source":"Crossref","is-referenced-by-count":92,"title":["Development and Retrospective Validation of the Juvenile Spondyloarthritis Disease Activity Index"],"prefix":"10.1002","volume":"66","author":[{"given":"Pamela F.","family":"Weiss","sequence":"first","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Colbert","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xiao","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Feudtner","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Beukelman","sequence":"additional","affiliation":[{"name":"University of Alabama Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esi Morgan","family":"DeWitt","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Pagnini","sequence":"additional","affiliation":[{"name":"University of Florence and Anna Meyer Children's Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey B.","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern, Texas Scottish Rite Hospital for Children Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Wallace","sequence":"additional","affiliation":[{"name":"University of Washington and Seattle Children's Hospital Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31820f8c99"},{"key":"e_1_2_7_3_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23721"},{"issue":"10","key":"e_1_2_7_5_1","first-page":"S105","article-title":"Enthesitis is a significant predictor of decreased quality of life, function, and arthritis\u2010specific pain across juvenile arthritis (JIA) categories: preliminary analyses from the CARRAnet registry","volume":"63","author":"Weiss P","year":"2011","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes004"},{"key":"e_1_2_7_7_1","first-page":"1122","article-title":"Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study","volume":"32","author":"Selvaag AM","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110427"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110145"},{"key":"e_1_2_7_10_1","first-page":"366","article-title":"Outcome and predictive factors in juvenile rheumatoid arthritis and juvenile spondyloarthropathy","volume":"25","author":"Flato B","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16676-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094870"},{"key":"e_1_2_7_13_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203046"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.10.941"},{"key":"e_1_2_7_18_1","first-page":"2290","article-title":"Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis","volume":"31","author":"Wallace CA","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00377-0"},{"key":"e_1_2_7_20_1","first-page":"198","article-title":"The OMERACT filter for Outcome Measures in Rheumatology","volume":"25","author":"Boers M","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_21_1","first-page":"789","article-title":"Preliminary validation of clinical remission criteria using the OMERACT filter for select categories of juvenile idiopathic arthritis","volume":"33","author":"Wallace CA","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_22_1","first-page":"713","article-title":"Design and validation of a new scale to assess the functional ability in children with juvenile idiopathic arthritis (JIA)","volume":"24","author":"Iglesias MJ","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101501"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202031"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-17"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22003"},{"key":"e_1_2_7_28_1","first-page":"1989","article-title":"Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort","volume":"29","author":"Oen K","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24539"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.2.198"},{"key":"e_1_2_7_31_1","first-page":"2256","article-title":"Prognosis of patients with juvenile chronic arthritis and juvenile spondyloarthropathy","volume":"27","author":"Minden K","year":"2000","journal-title":"J Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:54:18Z","timestamp":1759420458000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/acr.22411"],"URL":"https:\/\/doi.org\/10.1002\/acr.22411","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,24]]}}}