{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:50:30Z","timestamp":1772754630714,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nebraska Arthritis Outcomes Research Center"},{"name":"VA Health Services Research and Development Program of the Veterans Health Administration"},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bristol-Myers Squibb"},{"name":"VA Clinical Science Research & Development Career Development Award","award":["IK2 CX000955"],"award-info":[{"award-number":["IK2 CX000955"]}]},{"name":"VA Merit Clinical Science Research & Development Career Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess disease characteristics, disease activity, and treatment patterns in rheumatoid arthritis (RA) patients with comorbid hepatitis C virus (HCV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RA patients with concomitant HCV were identified within the Veterans Affairs Rheumatoid Arthritis Registry. HCV was defined as at least 1 diagnostic code present in medical record databases. Generalized estimating equations in linear regression models compared component and composite measures of disease activity between HCV\u2010positive and HCV\u2010negative patients over the study period, accounting for within\u2010subject correlations. Similar analysis of pharmacy databases evaluated medication use within each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two of 1,706 registry participants (5.1%) were identified with concomitant HCV. At enrollment, HCV\u2010positive patients were younger (mean \u00b1 SD 61.7 \u00b1 7.1 years versus 67.5 \u00b1 11.2 years; <jats:italic>P<\/jats:italic> &lt; 0.001), more often African American (35% versus 15%; <jats:italic>P<\/jats:italic> &lt; 0.001), and smokers (48% versus 26%; <jats:italic>P<\/jats:italic> &lt; 0.001). In unadjusted and adjusted analyses incorporating all study visits, patient\u2010reported outcomes (pain, tender joints, and patient global scores) were higher in HCV\u2010positive patients, contributing to higher disease activity scores. There was no difference in physician\u2010reported outcomes (swollen joints or physician global scores). HCV\u2010positive patients had lower C\u2010reactive protein levels (\u03b2 \u22120.30 [95% confidence interval (95% CI) \u22120.53, \u22120.07], <jats:italic>P =<\/jats:italic> 0.01). Over all visits, HCV\u2010positive patients were less likely to receive methotrexate (odds ratio [OR] 0.27 [95% CI 0.17, 0.40], <jats:italic>P<\/jats:italic> &lt; 0.001), and more likely to receive prednisone (OR 1.41 [95% CI 1.02, 1.97], <jats:italic>P<\/jats:italic> = 0.04) and anti\u2013tumor necrosis factor \u03b1 (anti\u2010TNF\u03b1) therapies (OR 1.51 [95% CI 1.04, 2.19], <jats:italic>P =<\/jats:italic> 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RA patients with concomitant HCV have higher disease activity scores, driven primarily by higher patient\u2010reported measures. HCV\u2010positive patients were more likely to be treated with prednisone and anti\u2010TNF\u03b1 therapies and less likely to receive methotrexate compared to HCV\u2010negative patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22463","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T14:46:27Z","timestamp":1409755587000},"page":"467-474","source":"Crossref","is-referenced-by-count":17,"title":["Disease Characteristics and Treatment Patterns in Veterans With Rheumatoid Arthritis and Concomitant Hepatitis C Infection"],"prefix":"10.1002","volume":"67","author":[{"given":"Ruchika","family":"Patel","sequence":"first","affiliation":[{"name":"Philadelphia VA Medical Center Pennsylvania, and University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Nebraska\u2010Western Iowa VA Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Richards","sequence":"additional","affiliation":[{"name":"VA Medical Center Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Kerr","sequence":"additional","affiliation":[{"name":"VA Medical Center, and Georgetown University and Howard University Hospitals Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Salt Lake City VA Medical Center and University of Utah Salt Lake City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Philadelphia VA Medical Center Pennsylvania, and University of 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