{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:08:32Z","timestamp":1760828912874,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify optimal cutoff values for body, hand, and wrist measurements in order to correctly identify individuals with carpal tunnel syndrome (CTS), using receiver operating characteristic (ROC) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled patients with CTS and control subjects at a 1:2 ratio, regardless of age and sex. The diagnosis of CTS was based on clinical findings and delayed distal conduction velocity of the median nerve. The anthropometric measurements included weight, height, waist circumference, hip circumferences, wrist depth\/width, third digit length, and palm length\/width. Obesity indicators and hand\/wrist ratios were calculated. Area under the ROC curve (AUC), sensitivity, specificity, and likelihood ratios were calculated separately according to sex. To assess the role of multiple anthropometric measurements, we fit multivariable logistic regression models including age, wrist ratio, shape index, body mass index, and waist\u2010to\u2010hip ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group comprised 1,117 subjects (250 female patients and 474 female controls; 120 male patients and 273 male controls). In women, the accuracy of all anthropometric measures was low (AUC \u22640.64). In men, the accuracy of the hand ratio, shape index, and wrist\u2010to\u2010palm ratio was moderate (AUC\u2009=\u20090.75). The estimates from the multivariable models confirmed the well\u2010known associations between the selected variables and the risk of CTS, but the use of multiple predictors did not dramatically improve the diagnostic performance observed for single anthropometric indexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In clinical practice, the cutoff values for many anthropometric measurements have limited value as tools for the diagnosis of CTS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22465","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T14:47:35Z","timestamp":1409755655000},"page":"691-700","source":"Crossref","is-referenced-by-count":26,"title":["Anthropometric Measurements as a Screening Test for Carpal Tunnel Syndrome: Receiver Operating Characteristic Curves and Accuracy"],"prefix":"10.1002","volume":"67","author":[{"given":"Mauro","family":"Mondelli","sequence":"first","affiliation":[{"name":"EMG Service Health District 7 Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Curti","sequence":"additional","affiliation":[{"name":"University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Farioli","sequence":"additional","affiliation":[{"name":"University of Bologna Bologna Italy Harvard School of Public Health Boston and The Cambridge Health Alliance Harvard Medical School Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Aretini","sequence":"additional","affiliation":[{"name":"EMG Service Health District 7 Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Ginanneschi","sequence":"additional","affiliation":[{"name":"University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Greco","sequence":"additional","affiliation":[{"name":"EMG Service Health District 7 Nottola Hospital Montepulciano Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Mattioli","sequence":"additional","affiliation":[{"name":"University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.2.153"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.2.289"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000338533.88960.b9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115753"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.54.10.734"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200203000-00007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHSB.2004.02.009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-343"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker108"},{"key":"e_1_2_6_11_1","first-page":"556","article-title":"Wrist dimensions: correlation with median sensory latencies","volume":"64","author":"Johnson EW","year":"1983","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170610"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00201-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.01.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20408"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00528.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.11.017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHSB.2003.09.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193408093326"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193408090142"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1195"},{"key":"e_1_2_6_23_1","first-page":"36","article-title":"Assessment of body mass index and hand anthropometric measurements as independent risk factors for carpal tunnel syndrome","volume":"67","author":"Sharifi\u2010Mollayousefi A","year":"2008","journal-title":"Folia Morphol (Warsz)"},{"key":"e_1_2_6_24_1","first-page":"193","article-title":"Association of anthropometric factors and predisposition to carpal tunnel syndrome","volume":"76","author":"Zyluk A","year":"2011","journal-title":"Chir Narzadow Ruchu Ortop Pol"},{"key":"e_1_2_6_25_1","first-page":"219","article-title":"Body mass index and anthropometric characteristics of the hand as risk factors for carpal tunnel syndrome","volume":"38","author":"Hlebs S","year":"2014","journal-title":"Coll Antropol"},{"key":"e_1_2_6_26_1","first-page":"270","article-title":"Wrist ratio correlation with carpal tunnel syndrome in industry","volume":"67","author":"Gordon C","year":"1988","journal-title":"Am J Phys Med Rehabil"},{"key":"e_1_2_6_27_1","first-page":"432","article-title":"Square wrists and carpal tunnel syndrome","volume":"86","author":"Edwards KS.","year":"1990","journal-title":"Ohio Med"},{"key":"e_1_2_6_28_1","first-page":"379","article-title":"Obesity as a risk factor for slowing of sensory conduction of the median nerve in industry: a cross\u2010sectional and longitudinal study involving 429 workers","volume":"34","author":"Nathan PA","year":"1992","journal-title":"J Occup Med"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199509000-00014"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.01.012"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.10.1447"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2406"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10185"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10926-006-9026-3"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.02.150"},{"key":"e_1_2_6_36_1","unstructured":"World Health Organization.Waist circumference and waist\u2010hip ratio report of a WHO expert consultation 8\u201311 December 2008. URL:http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241501491_eng.pdf."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039504"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2000000400005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.08.006"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4509"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.203"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241244"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199406000-00003"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199511000-00008"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199711000-00004"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880151007"},{"key":"e_1_2_6_48_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0749-0712(21)00309-7","article-title":"Anatomy of the median nerve at the wrist: open carpal tunnel release, classic","volume":"12","author":"Steinberg DR","year":"1996","journal-title":"Hand Clin"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-374"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22208"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22465","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:24:25Z","timestamp":1759422265000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/acr.22465"],"URL":"https:\/\/doi.org\/10.1002\/acr.22465","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}