{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:23:40Z","timestamp":1790468620230,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["AR-061362"],"award-info":[{"award-number":["AR-061362"]}]},{"name":"NIH","award":["AR-049880"],"award-info":[{"award-number":["AR-049880"]}]},{"name":"NIH","award":["AR-052403"],"award-info":[{"award-number":["AR-052403"]}]},{"name":"NIH","award":["AR-047782"],"award-info":[{"award-number":["AR-047782"]}]},{"name":"NIH","award":["AR-059073"],"award-info":[{"award-number":["AR-059073"]}]},{"name":"NIH","award":["CA-87969"],"award-info":[{"award-number":["CA-87969"]}]},{"name":"NIH","award":["CA-50385"],"award-info":[{"award-number":["CA-50385"]}]},{"name":"NIH","award":["CA-176726"],"award-info":[{"award-number":["CA-176726"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the association between a Mediterranean dietary pattern, as measured by the Alternate Mediterranean Diet Score (aMed), and risk of incident rheumatoid arthritis (RA) in US women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively followed 83,245 participants from the Nurses' Health Study (NHS; 1980\u20132008) and 91,393 participants from NHS II (1991\u20132009) who were initially free of baseline connective tissue diseases. Dietary information was obtained via validated food frequency questionnaires at baseline and approximately every 4 years during followup. The aMed score was calculated according to the consumption status of 9 food components using cumulative average value. Time\u2010varying Cox proportional hazards models were used to calculate hazard ratios (HRs) for RA, seropositive RA, and seronegative RA after adjustment for potential confounding factors. Results from 2 cohorts were pooled by an inverse variance\u2013weighted, fixed\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 3,511,050 person\u2010years of followup, 913 incident cases of RA were documented in the 2 cohorts. After adjustment for several lifestyle and dietary variables, in both cohorts greater adherence to Mediterranean dietary pattern was not significantly associated with altered risk of RA. The pooled HR for women in the highest quartile of the aMed score was 0.98 (95% confidence interval 0.80\u20131.20) compared with those in the bottom quartile. Similar nonsignificant results were observed for both seropositive and seronegative RA. We did not find significant associations between each individual food component (except for alcohol) of the aMed score and risk of incident RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find a significant association between a Mediterranean dietary pattern and the risk of RA in women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22481","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T10:12:00Z","timestamp":1411467120000},"page":"597-606","source":"Crossref","is-referenced-by-count":90,"title":["Mediterranean Diet and Incidence of Rheumatoid Arthritis in Women"],"prefix":"10.1002","volume":"67","author":[{"given":"Yang","family":"Hu","sequence":"first","affiliation":[{"name":"Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen H.","family":"Costenbader","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Harvard School of Public Health, Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Karlson","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1079\/PHN2005931","article-title":"The Mediterranean diet: science and practice","volume":"9","author":"Willett WC.","year":"2007","journal-title":"Public Health Nutr"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1344"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-6-22"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.12.1440"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1195"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.3.208"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.065151"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-2-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-2-26"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181b5f0ce"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.6.1077"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199605000-00007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816736"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.8.927"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27140"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(94)00096-C"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.04.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24716"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20621"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24350"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/18.4.858"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025039"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009849"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","unstructured":"LuB SolomonDH CostenbaderKH KarlsonEW.Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study. Arthritis Rheum2014;66:1998\u20132005.","DOI":"10.1002\/art.38634"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339709790192486"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91909-X"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90590-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20731"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2123"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf205"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-277X.2003.00423.x"},{"key":"e_1_2_7_37_1","first-page":"1249","article-title":"Diet and risk of rheumatoid arthritis in a prospective cohort","volume":"32","author":"Pedersen M","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.05.014"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","unstructured":"WaldschmidtTJ CookRT KovacsEJ.Alcohol and inflammation and immune responses: summary of the 2006 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol2008;42:137\u201342.","DOI":"10.1016\/j.alcohol.2007.11.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0275-7"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.3.459s"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500000271"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5001"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27425"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22481","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:24:29Z","timestamp":1759422269000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/acr.22481"],"URL":"https:\/\/doi.org\/10.1002\/acr.22481","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}