{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:01:01Z","timestamp":1793952061849,"version":"4.8.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["RO1-AR-4684"],"award-info":[{"award-number":["RO1-AR-4684"]}]},{"name":"Donald and Dorothy Stabler Foundation"},{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi\u2010square or Fisher's exact tests and used univariate and multivariate logistic regression models to assess the association between ulcers and clinical features such as malignancy, interstitial lung disease (ILD), and amyopathic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three patients (28%) had cutaneous ulcers. Nearly half the patients had ulcers present in more than 1 location: 24 (56%) had ulcers over the extensor surfaces of joints, 18 (42%) at the digital pulp or periungual areas, and 25 (58%) had ulcers located elsewhere. In univariate analysis ulcers were associated with Asian race, but not with other clinical and demographic features, including malignancy or ILD. In multivariate analysis ulcers were significantly associated with anti\u2013melanoma differentiation gene 5 (anti\u2010MDA5) antibodies (odds ratio 10.14, 95% confidence interval 1.95\u201352.78; <jats:italic>P<\/jats:italic>\u2009=\u20090.0059) and this was greatest for ulcers located at the digital pulp. In patients with cutaneous ulcers, ILD risk was specifically increased only in patients with anti\u2010MDA5\u2010positive antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirmed the strong association between anti\u2010MDA5 antibodies and cutaneous ulcers, with the novel finding that the association of cutaneous ulcers with ILD depends upon the presence of anti\u2010MDA5 antibodies. DM patients who display this cutaneous phenotype should undergo appropriate evaluation for ILD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22498","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T11:01:47Z","timestamp":1413802907000},"page":"667-672","source":"Crossref","is-referenced-by-count":154,"title":["Cutaneous Ulceration in Dermatomyositis: Association With Anti\u2013Melanoma Differentiation\u2013Associated Gene 5 Antibodies and Interstitial Lung Disease"],"prefix":"10.1002","volume":"67","author":[{"given":"Neera S.","family":"Narang","sequence":"first","affiliation":[{"name":"Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Casciola\u2010Rosen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Chung","sequence":"additional","affiliation":[{"name":"Stanford University, Stanford, and Palo Alto VA Health Care System Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.047"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985666"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00021-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.016"},{"key":"e_1_2_6_6_1","first-page":"85","article-title":"Cutaneous vasculitis in adult polymyositis\/dermatomyositis","volume":"10","author":"Feldman D","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.5.372"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00953.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.1289"},{"key":"e_1_2_6_11_1","first-page":"190","article-title":"Epidermal necrosis as a predictive sign of malignancy in adult dermatomyositis","volume":"61","author":"Mautner GH","year":"1998","journal-title":"Cutis"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.4.539-a"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0822-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep078"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21728"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182606f0b"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.041"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38093"},{"key":"e_1_2_6_21_1","first-page":"384","article-title":"Recurrent pneumomediastinum in adult dermatomyositis","volume":"16","author":"Cicuttini FM","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1994.tb01818.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90132-X"},{"key":"e_1_2_6_24_1","first-page":"903","article-title":"Role of endothelial damage in the pathogenesis of interstitial pneumonitis in patients with polymyositis and dermatomyositis","volume":"33","author":"Funauchi M","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02729.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1309\/CNQDMHLH2WGKL32T"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.9.780"},{"key":"e_1_2_6_28_1","first-page":"566","article-title":"Prolonged spontaneous pneumomediastinum in adult dermatomyositis","volume":"46","author":"Carmody E","year":"1987","journal-title":"Ann Rheum Dis"}],"container-title":["Arthritis Care &amp; 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