{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:33Z","timestamp":1791216393827,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["K23-AR-0259"],"award-info":[{"award-number":["K23-AR-0259"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["P60-AR-3308"],"award-info":[{"award-number":["P60-AR-3308"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rosalind Russell Medical Research Center for Arthritis at the University of California, San Francisco"},{"name":"NIH","award":["3UL1-RR-4131-04S1"],"award-info":[{"award-number":["3UL1-RR-4131-04S1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Dermatomyositis (DM) and polymyositis (PM) are debilitating inflammatory myopathies associated with significant mortality. We evaluated the relative contribution of infection to hospital mortality in a large population\u2010based study of individuals with PM\/DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data derive from the 2007 to 2011 Healthcare Cost and Utilization Project National Inpatient Samples and include all hospital discharges that met a validated administrative definition of PM\/DM. The primary outcome was hospital mortality. Variables for infections and comorbidities were generated from discharge diagnoses using validated administrative definitions. Logistic regression was used to investigate the relationship between infection and mortality in individuals with PM\/DM, adjusting for sociodemographics, utilization variables, and comorbidities. Relative risks (RRs) were calculated to compare the overall prevalence of specific infections and associated mortality in PM\/DM hospitalizations with those seen in the general hospitalized population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15,407 hospitalizations with PM\/DM met inclusion criteria for this study and inpatient mortality was 4.5% (700 deaths). In adjusted logistic regression analyses, infection (odds ratio [OR] 3.4, 95% confidence interval [95% CI] 2.9\u20134.0) was the strongest predictor of hospital mortality among individuals with PM\/DM. Bacterial infection (OR 3.5, 95% CI 3.0\u20134.1), comprised primarily of pneumonia and bacteremia, and opportunistic fungal infections (OR 2.5, 95% CI 1.5\u20134.0) were independently associated with hospital mortality. The overall burden of infection in hospitalizations with PM\/DM was significantly increased in comparison with the general hospitalized population (RR 1.5, 95% CI 1.4\u20131.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among hospitalized individuals with PM\/DM, infection is the leading cause of mortality. Strategies to mitigate infection risk in both the clinic and hospital settings should be evaluated to improve disease outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22501","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T11:02:53Z","timestamp":1413802973000},"page":"673-680","source":"Crossref","is-referenced-by-count":50,"title":["A Population\u2010Based Study of Infection\u2010Related Hospital Mortality in Patients With Dermatomyositis\/Polymyositis"],"prefix":"10.1002","volume":"67","author":[{"given":"Sara G.","family":"Murray","sequence":"first","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Schmajuk","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Trupin","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Lawson","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cascino","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Barton","sequence":"additional","affiliation":[{"name":"University of California San Francisco and San Francisco General Hospital San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Margaretten","sequence":"additional","affiliation":[{"name":"University of California San Francisco and San Francisco General Hospital San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia P.","family":"Katz","sequence":"additional","affiliation":[{"name":"University of California San Francisco and Phillip R. Lee Institute for Health Policy Studies San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward H.","family":"Yelin","sequence":"additional","affiliation":[{"name":"University of California San Francisco and Phillip R. Lee Institute for Health Policy Studies San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinoos","family":"Yazdany","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco General Hospital and Phillip R. 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