{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:49:30Z","timestamp":1793479770104,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute on Aging of the NIH","award":["R01-AG-034676"],"award-info":[{"award-number":["R01-AG-034676"]}]},{"name":"National Institute on Aging of the NIH","award":["UL1-TR-000135"],"award-info":[{"award-number":["UL1-TR-000135"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences (NCATS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine trends in the incidence and clinical presentation of ankylosing spondylitis (AS), the incidence of cardiovascular disease (CVD), and cardiovascular (CV) risk factors among patients with AS and compare the observed incidence of CVD with that predicted by the Framingham Risk Score (FRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based inception cohort of residents of Olmsted County, Minnesota age \u226518 years who fulfilled Modified New York Criteria for AS in 1980<jats:bold>\u2013<\/jats:bold>2009 was assembled. Clinical features at presentation were recorded. Age\u2010 and sex\u2010adjusted incidence rates and survival were estimated. Incident CVD and CV risk factors were identified. The 10\u2010year CVD risk was calculated using the FRS. Standardized incidence ratios (ratios of observed CVD in AS to that predicted by the FRS) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010six patients were diagnosed with AS over the study period with an age\u2010 and sex\u2010adjusted incidence of 3.1 per 100,000 (95% confidence interval [95% CI] 2.5<jats:bold>\u2013<\/jats:bold>3.8). The mean age at diagnosis was 35 years (range 19<jats:bold>\u2013<\/jats:bold>69 years). Inflammatory back pain, seen in 90% of patients, was the most common presenting manifestation. The 10\u2010year mean\u2009\u00b1\u2009SD cumulative incidence of CVD was 15.8%\u2009\u00b1\u20096.1%, three times higher than the predicted events based on the FRS (standardized incidence ratio 3.01, 95% CI 1.35\u20136.69; <jats:italic>P<\/jats:italic>\u2009=\u20090.007). Overall survival was similar to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AS occurs in approximately 3 persons per 100,000 per year. Clinical features, extraarticular manifestations, and interval from symptom onset to diagnosis have remained constant in this population over the study period. The CVD risk in these patients is higher than expected and underestimated by the FRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22512","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T14:19:12Z","timestamp":1415629152000},"page":"836-841","source":"Crossref","is-referenced-by-count":50,"title":["Time Trends in Incidence, Clinical Features, and Cardiovascular Disease in Ankylosing Spondylitis Over Three Decades: A Population\u2010Based Study"],"prefix":"10.1002","volume":"67","author":[{"given":"Kerry A.","family":"Wright","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement J.","family":"Michet","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Matteson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31820f8c99"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220408"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351211"},{"key":"e_1_2_6_6_1","first-page":"86","article-title":"Survival among patients with ankylosing spondylitis: a life\u2010table analysis","volume":"8","author":"Khan MA","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_1","first-page":"2167","article-title":"Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis","volume":"33","author":"Han C","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30581"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.18.1837"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1081-54"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq199"},{"key":"e_1_2_6_12_1","first-page":"496","article-title":"Incidence and prevalence of ankylosing spondylitis in Finland","volume":"24","author":"Kaipiainen\u2010Seppanen O","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21577"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/berh.2002.0243"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.513"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199507000-00001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.064717"},{"key":"e_1_2_6_19_1","unstructured":"Rochester Minnesota population: census 2010 and 2000 interactive map demographics statistics quick facts. 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