{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:09:05Z","timestamp":1793686145530,"version":"4.5.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Interleukin\u20106 (IL\u20106) is a key cytokine in rheumatoid arthritis pathogenesis. We aimed to analyze the association between IL\u20106 serum levels and joint inflammation at baseline and the correlation of time\u2010integrated IL\u20106 values with structural damage during the first 36 months of early arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IL\u20106 was assessed by 2 different methods in 813 patients of the French early arthritis cohort ESPOIR (Etude et Suivi des Polyarthrites Indiff\u00e9renci\u00e9es R\u00e9centes) over 36 months. IL\u20106 and C\u2010reactive protein (CRP) changes were correlated to radiographic progression assessed by the total Sharp\/van der Heijde score (SHS). Synovium inflammation was assessed in a subgroup of 126 patients by ultrasonography (US). The relationship between SHS change and IL\u20106 or CRP levels at baseline was investigated by a univariate regression and a multivariable analysis. A longitudinal model nested by visit and patient was conducted to assess the role of IL\u20106 on SHS at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, IL\u20106 was more strongly correlated with the swollen joint count than CRP level. In the univariate analysis, the time\u2010integrated value of IL\u20106 was more strongly correlated with the swollen joint count and the variation of SHS than time\u2010integrated CRP level. Baseline IL\u20106 was not independently associated with SHS change. Longitudinal models nested by patient showed that IL\u20106 levels were associated with structural damage independently from the Disease Activity Score in 28 joints, smoking status, rheumatoid factor, and anti\u2013citrullinated protein peptide antibody serology, treatments, and CRP levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u20106 level was a marker of US synovitis at baseline. Repeated measurements of IL\u20106 are associated with structural damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22513","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T14:19:14Z","timestamp":1415629154000},"page":"905-912","source":"Crossref","is-referenced-by-count":59,"title":["Evaluation of Serum Interleukin\u20106 Level as a Surrogate Marker of Synovial Inflammation and as a Factor of Structural Progression in Early Rheumatoid Arthritis: Results From a French National Multicenter Cohort"],"prefix":"10.1002","volume":"67","author":[{"given":"Athan","family":"Baillet","sequence":"first","affiliation":[{"name":"GREPI UJF CNRS Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Gossec","sequence":"additional","affiliation":[{"name":"UPMC Universit\u00e9 Paris 06, GRC\u2010UPMC 08 (EEMOIS), Assistance Publique H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Paternotte","sequence":"additional","affiliation":[{"name":"Paris\u2010Descartes University, Assistance Publique H\u00f4pitaux de Paris, Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Etcheto","sequence":"additional","affiliation":[{"name":"Paris\u2010Descartes University, Assistance Publique H\u00f4pitaux de Paris, Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Combe","sequence":"additional","affiliation":[{"name":"Lapeyronie University Hospital, Montpellier I University Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Meyer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 7 Denis Diderot, UFR de M\u00e9decine, and Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris, Universit\u00e9 Paris\u2010Sud, Institut Pour la Sant\u00e9 et la Recherche M\u00e9dicale Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques\u2010Eric","family":"Gottenberg","sequence":"additional","affiliation":[{"name":"Strasbourg University Hospital Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"Paris\u2010Descartes University, Assistance Publique H\u00f4pitaux de Paris, Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600904300"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep155"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200395"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203158"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10556"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.4.321"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.6.624"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200975"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.06.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21739"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030659"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24310"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep279"},{"key":"e_1_2_7_15_1","first-page":"2485","article-title":"Musculoskeletal ultrasound including definitions for ultrasonographic pathology","volume":"32","author":"Wakefield RJ","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_1","first-page":"1979","article-title":"Power Doppler ultrasound assessment of rheumatoid hand synovitis","volume":"28","author":"Stone M","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/513948"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30449"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.2.332"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.2.225"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381013"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201469"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33312"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123729"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123950"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110113"},{"key":"e_1_2_7_27_1","first-page":"38","article-title":"Modification of neutrophil function by plasma of rheumatoid arthritis patients treated with infliximab","volume":"24","author":"Dain L","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.1030"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22492"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10449"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213797109"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062463"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.11.1243"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201931"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23290"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2773"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121515"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4162"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.01.009"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32833cf3bc"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500701615017"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031562"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.318"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000130491.95823.94"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200338"},{"key":"e_1_2_7_46_1","first-page":"457","article-title":"Interleukin\u20101 \u03b2 in human plasma: optimization of blood collection, plasma extraction, and radioimmunoassay methods","volume":"7","author":"Cannon JG","year":"1988","journal-title":"Lymphokine Res"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0311"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0764"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/13547500903340570"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22513","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:50:49Z","timestamp":1759416649000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/acr.22513"],"URL":"https:\/\/doi.org\/10.1002\/acr.22513","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}