{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:23:17Z","timestamp":1781112197251,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"2013 Rheumatology Research Foundation Student Achievement Award"},{"name":"Consortium of Rheumatology Researchers of North America (CORRONA)"},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012754","name":"Horizon Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012754","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004312","name":"Lilly","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Momenta"},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009857","name":"Regeneron","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Vertex"},{"name":"UCB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Depression is common in the rheumatoid arthritis (RA) population, yet little is known of its effect on the course of disease activity. The aim of our study was to determine if prevalent and incident depressive symptoms influenced longitudinal changes in RA disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RA patients with and without depressive symptoms were identified using single\u2010item questions from an existing registry sample. Mixed\u2010effects models were used to examine changes in disease activity over 2 years in those with and without prevalent and incident depressive symptoms. Outcome variables included composite disease activity, joint counts, global assessments, pain, function, and acute\u2010phase reactants. Model\u2010based outcome estimations at the index dates and corresponding 1\u2010 and 2\u2010year changes were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rates of disease activity change were significantly different in patients with a lifetime prevalence of symptomology, but not incident depressive symptoms, when compared to controls. Prior symptoms were associated with slower rates of disease activity decline, evidenced by the estimated 1\u2010year Clinical Disease Activity Index changes: \u22123.0 (\u22123.3, \u22122.6) and \u22124.0 (\u22124.3, \u22123.6) in patients with and without lifetime prevalence, respectively. Analogous results were obtained for most of the other disease activity outcomes; although, there was no temporal effect of prevalent symptoms of depression on swollen joints and acute\u2010phase reactants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depressive symptoms temporally influence the evolution of RA disease activity, and the magnitude is dependent on the time of symptomatic onset. However, the effect is limited to patient\u2010reported pain, global assessment, and function, as well as physician\u2010reported global assessment and tender joints.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22515","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T14:19:15Z","timestamp":1415629155000},"page":"765-775","source":"Crossref","is-referenced-by-count":39,"title":["Temporal Effect of Depressive Symptoms on the Longitudinal Evolution of Rheumatoid Arthritis Disease Activity"],"prefix":"10.1002","volume":"67","author":[{"given":"Alan M.","family":"Rathbun","sequence":"first","affiliation":[{"name":"University of Maryland School of Medicine Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie R.","family":"Harrold","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Worcester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Reed","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Worcester and CORRONA Southborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23177"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.08.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2008.09.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket439"},{"key":"e_1_2_6_6_1","first-page":"523","article-title":"A description of patient\u2010 and rheumatologist\u2010reported depression symptoms in an American rheumatoid arthritis registry population","volume":"32","author":"Rathbun AM","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4108"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.11.62"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1521\/ijct.2008.1.3.192"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel231"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes356"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080147"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21602"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22249"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007991003795808"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.51.4.338"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24647"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200107000-00022"},{"key":"e_1_2_6_20_1","first-page":"457","article-title":"Immune activation and depression in women with rheumatoid arthritis","volume":"31","author":"Zautra AJ","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.06.033"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-007-9097-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"iv37","DOI":"10.1136\/ard.2005.043497","article-title":"The CORRONA database","volume":"64","author":"Kremer J.","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1007"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-40"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.9.5.478"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24428"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2013.001112"},{"key":"e_1_2_6_29_1","first-page":"144","article-title":"Do ultra\u2010short screening instruments accurately detect depression in primary care? A pooled analysis and meta\u2010analysis of 22 studies","volume":"57","author":"Mitchell AJ","year":"2007","journal-title":"Br J Gen Pract"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms900oa"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.041"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774508091749"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1740"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20265"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_6_38_1","volume-title":"Multilevel and longitudinal modeling using Stata","author":"Rabe\u2010Hesketh S","year":"2008"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.4.331"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2005.06.074"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.12.008"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.013"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.11.005"},{"key":"e_1_2_6_44_1","article-title":"Temporal associations between the different domains of rheumatoid arthritis disease activity and the onset of patient\u2010reported depressive symptoms","author":"Rathbun AM","journal-title":"Clin Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:34:34Z","timestamp":1759426474000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/acr.22515"],"URL":"https:\/\/doi.org\/10.1002\/acr.22515","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}