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We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age, sex, and body mass index were similar among ILI and DSE participants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSE participants (RR 0.85, 95% confidence interval 0.74\u20130.98). At year 4, this difference decreased to 5% and was no longer statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22544","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T10:11:00Z","timestamp":1424254260000},"page":"965-971","source":"Crossref","is-referenced-by-count":21,"title":["Can an Intensive Diet and Exercise Program Prevent Knee Pain Among Overweight Adults at High Risk?"],"prefix":"10.1002","volume":"67","author":[{"given":"Daniel K.","family":"White","sequence":"first","affiliation":[{"name":"University of Delaware, Newark, and Sargent College, Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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