{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:17:06Z","timestamp":1786976226181,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To establish agreement on systemic lupus erythematosus (SLE) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SLE experts (n\u2009=\u200969) were e\u2010mailed scenarios and indicated preferred treatments. Algorithms were constructed and agreement determined (\u226550% respondents indicating \u226570% agreement).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Initially, 54% (n\u2009=\u200937) responded suggesting treatment for scenarios; 13 experts rated agreement with scenarios. Fourteen of 16 scenarios had agreement as follows: discoid lupus: first\u2010line therapy was topical agents and hydroxychloroquine and\/or glucocorticoids then azathioprine and subsequently mycophenolate (mofetil); uncomplicated cutaneous vasculitis: initial treatment was glucocorticoids\u2009\u00b1\u2009hydroxychloroquine\u2009\u00b1\u2009methotrexate, followed by azathioprine or mycophenolate and then cyclophosphamide; arthritis: initial therapy was hydroxychloroquine and\/or glucocorticoids, then methotrexate and subsequently rituximab; pericarditis: first\u2010line therapy was nonsteroidal antiinflammatory drugs, then glucocorticoids with\/without hydroxychloroquine, then azathioprine, mycophenolate, or methotrexate and finally belimumab or rituximab, and\/or a pericardial window; interstitial lung disease\/alveolitis: induction was glucocorticoids and mycophenolate or cyclophosphamide, then rituximab or intravenous gamma globulin (IVIG), and maintenance followed with azathioprine or mycophenolate; pulmonary hypertension: glucocorticoids and mycophenolate or cyclophosphamide and an endothelin receptor antagonist were initial therapies, subsequent treatments were phosphodiesterase\u20105 inhibitors and then prostanoids and rituximab; antiphospholipid antibody syndrome: standard anticoagulation with\/without hydroxychloroquine, then a thrombin inhibitor for venous thrombosis, versus adding aspirin or platelet inhibition drugs for arterial events; mononeuritis multiplex and central nervous system vasculitis: first\u2010line therapy was glucocorticoids and cyclophosphamide followed by maintenance with azathioprine or mycophenolate, and then rituximab, IVIG, or plasmapheresis; and serious lupus nephritis: first\u2010line therapy was glucocorticoids and mycophenolate, then cyclophosphamide then rituximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We established variable agreement on treatment approaches. For some treatment decisions there was good agreement between experts even if no randomized controlled trial data were available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.22589","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T18:50:41Z","timestamp":1426531841000},"page":"1237-1245","source":"Crossref","is-referenced-by-count":99,"title":["Treatment Algorithms in Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"67","author":[{"given":"Chayawee","family":"Muangchan","sequence":"first","affiliation":[{"name":"Siriraj Hospital, Mahidol University, Bangkok, Thailand, and University of Western Ontario London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"van Vollenhoven","sequence":"additional","affiliation":[{"name":"Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha R.","family":"Bernatsky","sequence":"additional","affiliation":[{"name":"Montreal General Hospital, McGill University Health Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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