{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:27:30Z","timestamp":1791214050036,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the NIH"},{"name":"The Johns Hopkins Rheumatic Disease Research Core Center"},{"name":"NIH","award":["P30-AR-053503"],"award-info":[{"award-number":["P30-AR-053503"]}]},{"name":"NIH","award":["RO-1-AR-43727"],"award-info":[{"award-number":["RO-1-AR-43727"]}]},{"name":"NIH","award":["R01-NS-082563"],"award-info":[{"award-number":["R01-NS-082563"]}]},{"name":"NIH","award":["R56-AR-062615-01A1"],"award-info":[{"award-number":["R56-AR-062615-01A1"]}]},{"name":"The Huayi and Siuling Zhang Discovery Fund"},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Donald and Dorothy Stabler Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prior investigations demonstrated that autoantibodies recognizing cytosolic 5\u2032\u2010nucleotidase 1A (NT5C1A) are found in 33\u201376% of patients with inclusion body myositis (IBM) but are observed only rarely in patients with polymyositis (PM). Thus, anti\u2010NT5C1A may help distinguish IBM from PM. Although 4\u201321% of patients with dermatomyositis (DM) were shown to be anti\u2010NT5C1A antibody positive, the clinical features of anti\u2010NT5C1A\u2013positive patients with DM have not been described. Furthermore, the prevalence of anti\u2010NT5C1A antibodies in other rheumatic conditions has not been reported. This study was undertaken to define the prevalence and clinical features of anti\u2010NT5C1A\u2013positive patients with DM, PM, IBM, or other systemic autoimmune diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We screened for anti\u2010NT5C1A autoantibodies in patients with IBM, DM, PM, Sj\u00f6gren's syndrome (SS), or systemic lupus erythematosus (SLE) and in healthy volunteers. Clinical characteristics were compared between patients who were anti\u2010NT5C1A positive and those who were anti\u2010NT5C1A negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010NT5C1A autoantibodies were detected in 71 (61%) of 117 patients with IBM, 2 (5%) of 42 patients with PM, 2 (5%) of 42 healthy volunteers, 24 (15%) of 159 patients with DM, 10 (23%) of 44 patients with SS, and 13 (14%) of 96 patients with SLE. No anti\u2010NT5C1A antibody\u2013positive patients with SS or SLE had muscle involvement. Anti\u2010NT5C1A\u2013positive patients with IBM had a lower prevalence of rimmed vacuoles (62% versus 83% of antibody\u2010negative patients; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). No differences in the clinical characteristics of antibody\u2010positive and antibody\u2010negative patients with DM, SS, or SLE were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010NT5C1A is a common target of circulating autoantibodies, especially in IBM but also in several different autoimmune diseases. In SLE and SS, anti\u2010NT5C1A autoreactivity is not associated with muscle disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22600","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T11:02:59Z","timestamp":1429268579000},"page":"66-71","source":"Crossref","is-referenced-by-count":103,"title":["Cytosolic 5\u2032\u2010Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases"],"prefix":"10.1002","volume":"68","author":[{"given":"Thomas E.","family":"Lloyd","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Christopher\u2010Stine","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago","family":"Pinal\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Tiniakou","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Petri","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Baer","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonye K.","family":"Danoff","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Pak","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases\/NIH  Bethesda  Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia A.","family":"Casciola\u2010Rosen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Mammen","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases\/NIH, Bethesda, and Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260505"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/77.1.1019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.01.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1977"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23840"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23822"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000642"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305690"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21992"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.01.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.03.018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.268292"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328357f211"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02502.x"}],"container-title":["Arthritis Care &amp; 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