{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:01:10Z","timestamp":1789200070329,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Paracelsus Medical University Research Fund","award":["PMU FFF R-12702\/036\/BLO"],"award-info":[{"award-number":["PMU FFF R-12702\/036\/BLO"]}]},{"name":"Eli Lilly"},{"name":"NIH","award":["N01-AR-2-2258"],"award-info":[{"award-number":["N01-AR-2-2258"]}]},{"name":"NIH","award":["N01-AR-2-2259"],"award-info":[{"award-number":["N01-AR-2-2259"]}]},{"name":"NIH","award":["N01-AR-2-2260"],"award-info":[{"award-number":["N01-AR-2-2260"]}]},{"name":"NIH","award":["N01-AR-2-2261"],"award-info":[{"award-number":["N01-AR-2-2261"]}]},{"name":"NIH","award":["N01-AR-2-2262"],"award-info":[{"award-number":["N01-AR-2-2262"]}]},{"name":"Merck Research Laboratories"},{"name":"Novartis Pharmaceuticals"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pfizer, Inc."},{"name":"OAI Study Investigators"},{"name":"OAI is managed by the Foundation for the NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Medial meniscal extrusion is known to be related to structural progression of knee osteoarthritis. However, it is unclear whether medial meniscal extrusion is more strongly associated with cartilage loss in certain medial femorotibial subregions than in others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Segmentation of the medial tibial and femoral cartilage (baseline; 1\u2010year followup) and the medial meniscus (baseline) was performed in 60 participants with frequent knee pain (mean\u2009\u00b1\u2009SD ages 61.3\u2009\u00b1\u20099.2 years, body mass index 31.3\u2009\u00b1\u20093.9 kg\/m<jats:sup>2<\/jats:sup>) and with unilateral medial radiographic joint space narrowing (JSN) grades 1\u20133, using double\u2010echo steady\u2010state magnetic resonance images. Medial meniscal extrusion distance and extrusion area (percentage) between the external meniscal and tibial margin at baseline, and longitudinal medial cartilage loss in 8 anatomic subregions were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant association (Pearson's correlation coefficient) was seen between medial meniscal extrusion area in JSN knees and cartilage loss over 1 year throughout the entire medial femorotibial compartment. The strongest correlation was with cartilage loss in the external medial tibia (r\u2009=\u22120.34, <jats:italic>P<\/jats:italic> &lt; 0.01 in JSN; r\u2009=\u22120.30, <jats:italic>P<\/jats:italic>\u2009=\u20090.02 in knees without JSN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Medial meniscal extrusion was associated with subsequent medial cartilage loss. The external medial tibial cartilage may be particularly vulnerable to thinning once the meniscus extrudes and its surface is exposed to direct, nonphysiological, cartilage\u2010to\u2010cartilage contact.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22615","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T14:39:15Z","timestamp":1431959955000},"page":"1545-1552","source":"Crossref","is-referenced-by-count":71,"title":["Relationship Between Medial Meniscal Extrusion and Cartilage Loss in Specific Femorotibial Subregions: Data From the Osteoarthritis Initiative"],"prefix":"10.1002","volume":"67","author":[{"given":"K.","family":"Bloecker","sequence":"first","affiliation":[{"name":"Paracelsus Medical University, Salzburg, and Krankenhaus der Barmherzigen Schwestern Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wirth","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University, Salzburg, Austria, and Chondrometrics  Ainring Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine and Boston Imaging Core Lab Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, and University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Resch","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hochreiter","sequence":"additional","affiliation":[{"name":"Sisters of Charity Hospital Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University, Salzburg, Austria, and Chondrometrics  Ainring Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658050-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197506000-00027"},{"key":"e_1_2_7_4_1","first-page":"319","article-title":"Anatomy and physical examination of the knee menisci: a narrative review of the orthopedic literature","volume":"53","author":"Chivers MD","year":"2009","journal-title":"J Can Chiropr Assoc"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00003086-198006000-00039","article-title":"Load\u2010bearing mode of the knee joint: physical behavior of the knee joint with or without menisci","author":"Kurosawa H","year":"1980","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.08.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1181"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2010.05.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1274-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12110986"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2009.08.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2009.03.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24383"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23071"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2234-z"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023796"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2272"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21724"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.907323"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22380"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24791"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20149"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.015"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.12.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.113"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.06.016"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.02.010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-248"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327012"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23115"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-013-1769-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.08.041"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.008"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.11.003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.130278"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066183"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2012.04.005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.11.006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30414"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.10.011"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22016"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:53:25Z","timestamp":1759424005000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,27]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/acr.22615"],"URL":"https:\/\/doi.org\/10.1002\/acr.22615","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,27]]}}}