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The aim of this study was to evaluate the effect of vitamin D supplementation on disease activity and fatigue in juvenile\u2010onset SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a randomized, double\u2010blind, placebo\u2010controlled, 24\u2010week trial. Forty juvenile\u2010onset SLE patients were randomized (1:1) to receive oral cholecalciferol 50,000 IU\/week (juvenile\u2010onset SLE\u2010VitD) or placebo (juvenile\u2010onset SLE\u2010PL). Medications remained stable throughout the study. Serum levels of 25(OH)D were measured using radioimmunoassay. Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the European Consensus Lupus Activity Measurement (ECLAM). Fatigue was assessed using the Kids Fatigue Severity Scale (K\u2010FSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, groups were similar regarding age, body mass index, organ involvement, glucocorticoid dose, use of immunosuppressive drugs, SLEDAI, ECLAM, K\u2010FSS, and levels of 25(OH)D. After 24 weeks, the mean level of 25(OH)D was higher in the juvenile\u2010onset SLE\u2010VitD group than in the juvenile\u2010onset SLE\u2010PL group (<jats:italic>P<\/jats:italic> &lt; 0.001). At the end of the intervention, a significant improvement in SLEDAI (<jats:italic>P<\/jats:italic>\u2009=\u20090.010) and in ECLAM (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) was observed in the juvenile\u2010onset SLE\u2010VitD group compared to the juvenile\u2010onset SLE\u2010PL group. Regarding fatigue evaluation, a reduction of fatigue related to social life score was found in the juvenile\u2010onset SLE\u2010VitD group compared to the juvenile\u2010onset SLE\u2010PL group (<jats:italic>P<\/jats:italic>\u2009=\u20090.008). Cholecalciferol was well tolerated with no serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that cholecalciferol supplementation for 24 weeks is effective in decreasing disease activity and improving fatigue in juvenile\u2010onset SLE patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22621","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T14:40:21Z","timestamp":1431960021000},"page":"91-98","source":"Crossref","is-referenced-by-count":146,"title":["Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"68","author":[{"given":"Glauce L.","family":"Lima","sequence":"first","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Paupitz","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia E.","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliam","family":"Takayama","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Bonfa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M. 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