{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:10:22Z","timestamp":1790799022354,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000142","name":"The Arthritis Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004089","name":"Krembil Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004089","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral Research Award from the Canadian Institutes of Health Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To further explore the \u201cparent\u2010of\u2010origin\u201d effect in a large cohort of well\u2010phenotyped patients with cutaneous psoriasis without arthritis (PsC) and psoriatic arthritis (PsA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Self\u2010reported family history was obtained from PsA patients from Toronto and Newfoundland satisfying the Classification of Psoriatic Arthritis criteria, and PsC patients from Toronto, who were examined by a rheumatologist to exclude PsA. Proportions of probands with paternally and maternally transmitted psoriatic disease were compared by McNemar's and chi\u2010square tests. Baseline clinical and genetic characteristics of probands with paternally and maternally transmitted disease were compared using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 849 probands reported a first\u2010degree relative affected with psoriatic disease (PsC or PsA), of which 532 (63%) reported an affected parent. A significantly larger proportion of probands reported an affected father compared to an affected mother with psoriatic disease (289 [57%] versus 220 [43%], respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.003). This paternal transmission bias was evident in PsA (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) and PsC probands, although it did not reach statistical significance in PsC probands (<jats:italic>P<\/jats:italic>\u2009=\u20090.20). Furthermore, the proportion of paternal PsC\u2013proband PsA pairs (161 of 214 paternal transmissions [75%]) was significantly larger than maternal PsC\u2013proband PsA pairs (103 of 161 maternal transmissions [64%]) (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Newfoundland probands with paternally transmitted disease had higher <jats:italic>HLA\u2013B*08<\/jats:italic> carriage (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) and lower <jats:italic>MICA\u2013129Met<\/jats:italic> carriage (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Males had higher <jats:italic>HLA\u2013B*38<\/jats:italic> carriage (<jats:italic>P<\/jats:italic>\u2009=\u20090.05) and a higher prevalence of nail lesions (<jats:italic>P<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have provided further epidemiologic evidence of a paternal transmission bias in psoriatic disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22625","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:08:08Z","timestamp":1432735688000},"page":"1586-1590","source":"Crossref","is-referenced-by-count":18,"title":["Further Evidence Supporting a Parent\u2010of\u2010Origin Effect in Psoriatic Disease"],"prefix":"10.1002","volume":"67","author":[{"given":"Remy A.","family":"Pollock","sequence":"first","affiliation":[{"name":"Toronto Western Hospital and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arane","family":"Thavaneswaran","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawnda","family":"Pellett","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Chandran","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Art","family":"Petronis","sequence":"additional","affiliation":[{"name":"Centre for Addition and Mental Health Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Proton","family":"Rahman","sequence":"additional","affiliation":[{"name":"Memorial University of Newfoundland, St. John's Newfoundland Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna D.","family":"Gladman","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1155","volume-title":"Kelley's textbook of rheumatology","author":"Gladman D.","year":"2005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058453"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20496"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.030775"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201357"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420504"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00213.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1228::AID-ANR20>3.0.CO;2-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09831.x"},{"key":"e_1_2_7_13_1","first-page":"165","article-title":"Nail changes in psoriasis: a profile","volume":"21","author":"Puri N","year":"2011","journal-title":"J Pakistan Assoc Dermatolo"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319304"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0770-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002960100135"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12213"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg257"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320510218"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/345646"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-eular.3309"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063619"},{"key":"e_1_2_7_23_1","first-page":"824","article-title":"Accuracy of self\u2010reported family history in psoriatic arthritis [letter]","volume":"27","author":"Rahman P","year":"2000","journal-title":"J Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22625","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:53:19Z","timestamp":1759423999000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,27]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/acr.22625"],"URL":"https:\/\/doi.org\/10.1002\/acr.22625","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,27]]}}}