{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:12:37Z","timestamp":1779905557216,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the rheumatoid arthritis (RA) characteristics associated with increased herpes zoster (HZ) risk in the Corrona registry RA patients, and to evaluate the risk in initiators of tumor necrosis factor inhibitors (TNFi) or non\u2010TNFi biologic agents or (among those who were currently on or had been previously treated with methotrexate [MTX]) conventional synthetic disease\u2010modifying antirheumatic drugs (csDMARDs) other than MTX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cox regression modeling estimated the association between first HZ incidence and selected RA characteristics, including disease activity. Medication\u2010related risk for HZ in RA patients taking current or past MTX (to exclude milder RA disease) were categorized by treatment initiation (TNFi versus non\u2010TNFi versus csDMARD). Hazard ratios (HRs) estimated HZ risk of each treatment initiation category after stratification on trimmed propensity score (PS) quintiles to control for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28,852 patients contributed 95,287 person\u2010years. Seven hundred twenty\u2010nine observed HZ cases yielded a 7.7 (95% confidence interval [95% CI] 7.1\u20138.2) per 1,000 patient\u2010years crude incidence rate, lower than found in prior RA cohorts. However, consistent with prior studies, increasing age (HR 1.14, 95% CI 1.09\u20131.19 per 5 years) and prednisone therapy \u22657.5 mg\/day (HR 1.81, 95% CI 1.23\u20132.67) were associated with a higher HZ risk. Referent to TNFi exposure, PS\u2010stratified analysis showed an HR for csDMARDs of 1.36 (95% CI 0.82\u20132.25) and for non\u2010TNFi of 0.83 (95% CI 0.51\u20131.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the Corrona registry, the HZ risk in RA patients taking prior or current MTX increased with older age and higher prednisone dose. The HZ risk among these patients with RA was comparable after initiation of TNFi versus non\u2010TNFi versus csDMARDs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22628","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:07:40Z","timestamp":1432735660000},"page":"1671-1678","source":"Crossref","is-referenced-by-count":79,"title":["Herpes Zoster Reactivation in Patients With Rheumatoid Arthritis: Analysis of Disease Characteristics and Disease\u2010Modifying Antirheumatic Drugs"],"prefix":"10.1002","volume":"67","author":[{"given":"Dimitrios A.","family":"Pappas","sequence":"first","affiliation":[{"name":"Columbia University College of Physicians and Surgeons, New York, New York, and Corrona Southborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Hooper","sequence":"additional","affiliation":[{"name":"Amgen Thousand Oaks 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