{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:06:49Z","timestamp":1791612409001,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Rheumatology Research Foundation Scientist Development Award"},{"name":"NIH Loan Repayment Award","award":["L30-AR-066953"],"award-info":[{"award-number":["L30-AR-066953"]}]},{"name":"NIH\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["AR-049880"],"award-info":[{"award-number":["AR-049880"]}]},{"name":"NIH\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["AR-052403"],"award-info":[{"award-number":["AR-052403"]}]},{"name":"NIH\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["AR-047782"],"award-info":[{"award-number":["AR-047782"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of weight loss after bariatric surgery among patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of RA patients who underwent bariatric surgery (Roux\u2010en\u2010Y gastric bypass, laparoscopic adjustable gastric banding, or sleeve gastrectomy) at 2 medical centers. We obtained information on anthropometrics, laboratory values, RA disease activity, and medication use at baseline (prior to surgery), at 6 and 12 months following surgery, and at the most recent followup visits. RA disease activity was determined by clinical or validated measures. At each postsurgical visit, characteristics were compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 53 RA patients who underwent bariatric surgery. At baseline prior to surgery, mean\u2009\u00b1\u2009SD body mass index was 47.8\u2009\u00b1\u20097.7 kg\/m<jats:sup>2<\/jats:sup>, mean\u2009\u00b1\u2009SD weight was 128.2\u2009\u00b1\u200924.1 kg, and 57% had moderate to high RA disease activity. Twelve months following surgery, subjects lost a mean\u2009\u00b1\u2009SD weight of 41.0\u2009\u00b1\u200917.3 kg, mean\u2009\u00b1\u2009SD 70%\u2009\u00b1\u200924% excess weight (<jats:italic>P<\/jats:italic> &lt; 0.001). RA disease activity significantly improved at postsurgical visits (<jats:italic>P<\/jats:italic> &lt; 0.001). At 12 months following surgery, 6% had moderate to high disease activity, compared to 57% at baseline (<jats:italic>P<\/jats:italic> &lt; 0.001). At the most recent followup (mean\u2009\u00b1\u2009SD 5.8\u2009\u00b1\u20093.2 years after surgery), 74% were in remission, compared to 26% at baseline (<jats:italic>P<\/jats:italic> &lt; 0.001). Subjects had significantly lower erythrocyte sedimentation rate, C\u2010reactive protein level, and RA\u2010related medication use at followup visits compared to baseline (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After substantial weight loss from bariatric surgery, RA patients had lower disease activity, decreased serum inflammatory markers, and less RA\u2010related medication use. Weight loss may be an important nonpharmacologic strategy to reduce RA disease activity. However, other factors, such as improved efficacy of medications, improved physical activity, and metabolic changes, may also have contributed to these postsurgical improvements.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22629","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:08:46Z","timestamp":1432735726000},"page":"1619-1626","source":"Crossref","is-referenced-by-count":82,"title":["Impact of Bariatric Surgery on Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"67","author":[{"given":"Jeffrey A.","family":"Sparks","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Halperin","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan 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