{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:03:08Z","timestamp":1791979388635,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["RP-PG-0407-10070"],"award-info":[{"award-number":["RP-PG-0407-10070"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is limited information about the extent to which the association between preoperative and chronic postoperative pain is mediated via pain\u2010on\u2010movement or pain\u2010at\u2010rest. We explored these associations in patients undergoing total hip replacement (THR) and total knee replacement (TKR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 322 and 316 patients receiving THR and TKR, respectively, were recruited into a single\u2010center UK cohort (Arthroplasty Pain Experience) study. Preoperative, acute postoperative, and 12\u2010month pain severity was measured using self\u2010reported pain instruments. The association between preoperative\/acute pain and chronic postoperative pain was investigated using structural equation modeling (SEM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with high levels of preoperative pain were more likely to report chronic pain after THR (\u03b2\u2009=\u20090.195, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and TKR (\u03b2\u2009=\u20090.749, <jats:italic>P<\/jats:italic> &lt; 0.0001). Acute postoperative pain\u2010on\u2010movement was not associated with chronic pain after TKR or THR after adjusting for preoperative pain; however, acute pain\u2010at\u2010rest was associated with chronic pain after THR (\u03b2\u2009=\u20090.20, <jats:italic>P<\/jats:italic> &lt; 0.0002) but not TKR after adjusting for preoperative pain. Analysis of pain\u2010at\u2010rest and pain\u2010on\u2010movement highlighted differences between THR and TKR patients. Chronic pain\u2010at\u2010rest after THR was weakly associated with pain\u2010at\u2010rest during the preoperative (\u03b2\u2009=\u20090.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.068) and acute postoperative period (\u03b2\u2009=\u20090.21, <jats:italic>P<\/jats:italic> &lt; 0.0001). In contrast, chronic pain\u2010on\u2010movement after TKR was strongly associated with the severity of pain\u2010on\u2010movement during the preoperative period (\u03b2\u2009=\u20090.51, <jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SEM illustrated the different patterns of association between measures of pain over time in patients undergoing THR and TKR for osteoarthritis. These findings highlight the importance of future work that explores the mechanisms underlying pain\u2010on\u2010movement and pain\u2010at\u2010rest.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22656","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T17:36:57Z","timestamp":1437759417000},"page":"237-245","source":"Crossref","is-referenced-by-count":59,"title":["Rest Pain and Movement\u2010Evoked Pain as Unique Constructs in Hip and Knee Replacements"],"prefix":"10.1002","volume":"68","author":[{"given":"Adrian","family":"Sayers","sequence":"first","affiliation":[{"name":"School of Clinical Sciences, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki","family":"Wylde","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Lenguerrand","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Beswick","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Gooberman\u2010Hill","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pyke","sequence":"additional","affiliation":[{"name":"North Bristol National Health Service Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dieppe","sequence":"additional","affiliation":[{"name":"University of Exeter Medical School  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley W.","family":"Blom","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Joint Registry. 11th Annual Report Hemel Hempstead: NJR Centre. 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2010.12.003"},{"key":"e_1_2_7_4_1","first-page":"e000435","article-title":"What proportion of patients report long\u2010term pain after total hip or knee replacement for osteoarthritis? 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