{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:51:08Z","timestamp":1767923468767,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether calcinosis and acro\u2010osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NVC and bilateral hand radiographs were systematically performed in 155 consecutively recruited patients with SSc during a 24\u2010month period. Radiologic assessment of calcinosis and acro\u2010osteolysis was performed blinded for the results on NVC features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with calcinosis (n\u2009=\u200929) or acro\u2010osteolysis (n\u2009=\u200925) on radiographs were more likely to have the late pattern on NVC, defined by severe loss of capillaries and neoangiogenesis (<jats:italic>P<\/jats:italic>\u2009=\u20090.003 and <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). A reduced number of capillaries was significantly found in patients with calcinosis (mean\u2009\u00b1\u2009SD 3.55\u2009\u00b1\u20091.76 versus 5.53\u2009\u00b1\u20092.32 capillaries per finger; <jats:italic>P<\/jats:italic> &lt; 0.001) and acro\u2010osteolysis (mean\u2009\u00b1\u2009SD 2.88\u2009\u00b1\u20091.30 versus 5.60\u2009\u00b1\u20092.26 capillaries per finger; <jats:italic>P<\/jats:italic> &lt; 0.001). In addition, neoangiogenesis was more frequently observed in patients with severe acro\u2010osteolysis (<jats:italic>P<\/jats:italic>\u2009=\u20090.021). Multivariate logistic regression analysis confirmed the independent association between the late NVC pattern and calcinosis (odds ratio [OR] 3.04, 95% confidence interval [95% CI] 1.20\u20137.68) or acro\u2010osteolysis (OR 4.57, 95% CI 1.66\u201312.55), together with history of and\/or active digital ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acro\u2010osteolysis and calcinosis are independently associated with the late NVC pattern and particularly with severe capillary loss. These results strengthen the link between these radiographic lesions and digital destructive vasculopathy. Moreover, severe acro\u2010osteolysis was more likely to occur with neoangiogenesis, which may suggest an attempt to compensate bone resorption. Further studies are now needed to better understand the physiopathology of calcinosis and acro\u2010osteolysis and determine whether any agent may modify the course of these lesions by influencing vessel damages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22672","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T21:56:48Z","timestamp":1438207008000},"page":"366-373","source":"Crossref","is-referenced-by-count":49,"title":["Late Nailfold Videocapillaroscopy Pattern Associated With Hand Calcinosis and Acro\u2010Osteolysis in Systemic Sclerosis"],"prefix":"10.1002","volume":"68","author":[{"given":"La\u00ebtitia","family":"Morardet","sequence":"first","affiliation":[{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Cochin Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Avouac","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Sorbonne Paris 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