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We compared incidence rates of PE, DVT, and VTE between the 2 groups according to SSc disease duration. We calculated hazard ratios (HRs), adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,245 individuals with SSc (83% female, mean age 56 years), the incidence rates of PE, DVT, and VTE were 3.47, 3.48, and 6.56 per 1,000 person\u2010years, respectively, whereas the corresponding rates were 0.78, 0.76, and 1.37 per 1,000 person\u2010years among 12,670 non\u2010SSc individuals. Compared with non\u2010SSc individuals, the multivariable HRs among SSc patients were 3.73 (95% confidence interval [95% CI] 1.98\u20137.04), 2.96 (95% CI 1.54\u20135.69), and 3.47 (95% CI 2.14\u20135.64) for PE, DVT, and VTE, respectively. The age\u2010, sex\u2010, and entry time\u2013matched HRs for PE, DVT, and VTE were highest during the first year after SSc diagnosis (32.77 [95% CI 6.60\u2013162.75], 8.50 [95% CI 3.13\u201323.04], and 12.03 [95% CI 5.27\u201327.45], respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide population\u2010based evidence that SSc patients are at a substantially increased risk of VTE, especially within the first year after SSc diagnosis. Increased monitoring for this potentially fatal outcome and its modifiable risk factors is warranted in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22673","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T23:46:55Z","timestamp":1437781615000},"page":"246-253","source":"Crossref","is-referenced-by-count":52,"title":["Risk of Pulmonary Embolism and Deep Venous Thrombosis in Systemic Sclerosis: A General Population\u2010Based Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Sara R.","family":"Schoenfeld","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School, Boston, and Arthritis Research Canada Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Sayre","sequence":"additional","affiliation":[{"name":"Arthritis Research Canada Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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