{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:23:25Z","timestamp":1780957405168,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MIUR PRIN 2012 to S.L.","award":["2012SNMJRL"],"award-info":[{"award-number":["2012SNMJRL"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The interferon\u2010inducible protein 16 (IFI16) has been detected in sera from patients with autoimmune\/inflammatory diseases, but not in healthy subjects. This leaking leads to loss of tolerance toward this self\u2010protein and the development of autoantibodies. In this study, clinical significance of both IFI16 protein and anti\u2010IFI16 antibodies in rheumatoid arthritis (RA) was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IFI16 protein and anti\u2010IFI16 antibody levels were assessed by enzyme\u2010linked immunosorbent assay in serum samples from 154 RA patients and 182 healthy controls, and in synovial fluid (SF) samples from 21 RA patients and 25 patients with osteoarthritis (OA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean serum levels for both IFI16 and anti\u2010IFI16 antibodies were higher in RA patients than in healthy controls, with a direct correlation between IFI16 concentration and anti\u2010IFI16 antibody titer. The majority of RA patients with detectable circulating IFI16 protein were also positive for rheumatoid factor (RF)\/anti\u2013cyclic citrullinated peptide antibody (anti\u2010CCP). The latter group was found to be positive for anti\u2010IFI16 antibodies as well. The mean SF concentrations of both IFI16 protein and anti\u2010IFI16 antibodies were higher in RA patients when compared with control OA patients. Interestingly, the presence of circulating IFI16 protein, but not anti\u2010IFI16 antibodies, significantly correlated with RA\u2010associated pulmonary disease. This correlation was not dependent on the presence of anti\u2010IFI16 antibodies, sex, and smoking habit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate that the high levels of circulating IFI16 in RA are more frequent in RF\/anti\u2010CCP\u2013positive RA patients and significantly associated with pulmonary involvement. The relevance of circulating IFI16 protein as a new clinical biomarker of RA should be verified with additional studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22695","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T10:36:29Z","timestamp":1440758189000},"page":"440-445","source":"Crossref","is-referenced-by-count":31,"title":["Circulating Interferon\u2010Inducible Protein IFI16 Correlates With Clinical and Serological Features in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"68","author":[{"given":"Alessia","family":"Alunno","sequence":"first","affiliation":[{"name":"University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Caneparo","sequence":"additional","affiliation":[{"name":"Novara Medical School Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onelia","family":"Bistoni","sequence":"additional","affiliation":[{"name":"University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Caterbi","sequence":"additional","affiliation":[{"name":"University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Terenzi","sequence":"additional","affiliation":[{"name":"University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Gariglio","sequence":"additional","affiliation":[{"name":"Novara Medical School Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bartoloni","sequence":"additional","affiliation":[{"name":"University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Manzo","sequence":"additional","affiliation":[{"name":"IRCCS Policlinico S. 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