{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:24:18Z","timestamp":1783956258111,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the associations between body composition and hormonal and inflammatory factors measured 5 years prior and tibial cartilage volume in young adults, and to explore if these factors contribute to the sex difference in tibial cartilage volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects broadly representative of the young adult Australian population (n\u2009=\u2009328, ages 31\u201341 years, 47.3% women) were selected. They underwent T1\u2010weighted fat\u2010suppressed magnetic resonance imaging (MRI) of their knees. Tibial cartilage volume was measured from MRI. Sex hormone binding globulin (SHBG) and testosterone in a subset of women and C\u2010reactive protein (CRP) level and fibrinogen in both sexes were measured 5 years prior. Body mass index (BMI), fat mass, and lean mass were calculated from height, weight, and skinfolds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In multivariable analyses, correlates of tibial cartilage volume included lean body mass (\u03b2\u2009=\u200926.4 mm<jats:sup>3<\/jats:sup>; 95% confidence interval [95% CI] 13.6, 39.1), fat mass (\u03b2\u2009=\u2009\u221211.8 mm<jats:sup>3<\/jats:sup>; 95% CI \u221222.2, \u22121.4), and fibrinogen (\u03b2\u2009=\u2009\u2212146.4 mm<jats:sup>3<\/jats:sup>; 95% CI \u2212276.4, \u221216.4), but not BMI, testosterone, or CRP level. In women, SHBG was positively associated with tibial cartilage volume (\u03b2\u2009=\u20090.67 mm<jats:sup>3<\/jats:sup>; 95% CI 0.14, 1.20) and Free Androgen Index was negatively associated with lateral tibial cartilage volume (\u03b2\u2009=\u2009\u22120.04 mm<jats:sup>3<\/jats:sup>; 95% CI \u22120.07, 0.00). Men had 13% more tibial cartilage volume (500 mm<jats:sup>3<\/jats:sup>) than women. The magnitude of this association decreased by 38%, 20%, and 37% after adjustment for lean body mass, fat mass, and fibrinogen, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Body composition, sex hormones, and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and\/or fibrinogen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22715","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T09:48:54Z","timestamp":1442656134000},"page":"517-525","source":"Crossref","is-referenced-by-count":21,"title":["Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults"],"prefix":"10.1002","volume":"68","author":[{"given":"Benny","family":"Antony","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Venn","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania Hobart 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