{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:25:22Z","timestamp":1773455122339,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["17390177, 20390187, 23390177"],"award-info":[{"award-number":["17390177, 20390187, 23390177"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine cross\u2010sectionally whether intraabdominal fat area (IAFA), i.e., visceral fat, and liver fat assessed by computed tomography (CT) are independently associated with hyperuricemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were 801 Japanese men not taking antidiabetic, antihypertensive, or urate\u2010lowering medications, without any history of renal disease, cardiovascular disease, or cancer, and with serum creatinine &lt;1.5 mg\/dl. Abdominal, thoracic, and thigh fat areas were measured by CT. Total fat area (TFA) was the sum of these fat areas. Total subcutaneous fat area (TSFA) was TFA minus IAFA. Liver fat was assessed by liver\u2010to\u2010spleen (L\/S) ratio measured by CT. Hyperuricemia was defined as serum uric acid level &gt;7.0 mg\/dl. Its association with adiposity was tested using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of hyperuricemia was 19.6% (157 men). Both greater IAFA and lower L\/S ratio were independently associated with hyperuricemia in models that simultaneously included IAFA and L\/S ratio: multiple\u2010adjusted odds ratios of hyperuricemia for quintiles 3, 4, and 5 of IAFA were 2.16 (95% confidence interval [95% CI] 1.02\u20134.59), 2.41 (95% CI 1.13\u20135.16), and 4.00 (95% CI 1.81\u20138.85), respectively, compared to quintile 1, and the L\/S ratios for quintiles 3, 2, and 1 were 2.34 (95% CI 1.16\u20134.75), 2.15 (95% CI 1.06\u20134.34), and 2.79 (95% CI 1.35\u20135.76), respectively, compared to quintile 5. Both IAFA and L\/S ratio remained significant even after adjusting for abdominal subcutaneous fat area, TFA, TSFA, body mass index, or waist circumference. Of all fat measurements, IAFA had the strongest association with hyperuricemia by Akaike's information criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Greater amounts of both visceral fat and liver fat were independently associated with hyperuricemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22729","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T12:37:44Z","timestamp":1443443864000},"page":"553-561","source":"Crossref","is-referenced-by-count":56,"title":["Association of Visceral Fat and Liver Fat With Hyperuricemia"],"prefix":"10.1002","volume":"68","author":[{"given":"Akiko","family":"Yamada","sequence":"first","affiliation":[{"name":"Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko K.","family":"Sato","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kinuhata","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Uehara","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginji","family":"Endo","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonezo","family":"Hikita","sequence":"additional","affiliation":[{"name":"Ohtori Health Promotion Center Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfred Y.","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"University of Washington Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Boyko","sequence":"additional","affiliation":[{"name":"Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, and University of Washington Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoshige","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine, Osaka, Japan, and University of Washington Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3199"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20344"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056864"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-419"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20065"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24612"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.08.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/4.1.20"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070893"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4262"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.0045"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90210-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23593"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.234062"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.271"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290054029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800530"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.2.271"},{"issue":"1","key":"e_1_2_7_22_1","first-page":"47S","article-title":"Use of computed tomography regional fat areas to estimate adiposity: correlation with hydrodensitometry, bioelectrical impedence, skinfold thickness, and body mass index [abstract]","volume":"7","author":"McNeely MJ","year":"1999","journal-title":"Obes Res"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05420.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15257770.2011.596496"},{"key":"e_1_2_7_25_1","first-page":"185","volume-title":"Multicollinearity and what to do about it: primer of applied regression & analysis of variance","author":"Glantz SA","year":"2001"},{"key":"e_1_2_7_26_1","first-page":"259","volume-title":"Information criteria tests: logistic regression models. Chapman & Hall\/CRC texts in statistical science series","author":"Hilbe JM.","year":"2009"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.11.021"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80194-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.08.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr291"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.02.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2013.03.007"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-25"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1756"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1378"},{"key":"e_1_2_7_36_1","first-page":"841","article-title":"The influence of fatty liver on insulin clearance and insulin resistance in non\u2010diabetic Japanese subjects","volume":"19","author":"Goto T","year":"1995","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.400"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.1.E1"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000237"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602153340707"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.526138"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.5491\/SHAW.2012.3.4.287"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:52:55Z","timestamp":1759420375000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,24]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/acr.22729"],"URL":"https:\/\/doi.org\/10.1002\/acr.22729","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,24]]}}}