{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:28:20Z","timestamp":1790137700813,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Cutaneous telangiectasia (CT) are common in systemic sclerosis (SSc) patients, but their ability to stratify patients by risk is poorly known. We aimed to determine whether the number and size of CT were associated with the pattern of microvascular lesions assessed by nailfold videocapillaroscopy (NVC) and markers reflecting the severity of SSc\u2010related vasculopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study, including consecutive SSc patients over a 6\u2010month period. We also considered 3 predefined subsets of patients according to the number of hand or face CT: absence, \u226410, or &gt;10 hand or face CT (profuse CT). Pseudotumoral CT were defined as CT with &gt;5 mm diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 87 patients were included, of whom 75 (86%) had CT (27 with profuse and 19 with pseudotumoral CT). Profuse and pseudotumoral CT were both associated with capillary loss (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.002, respectively) and severe neoangiogenesis (<jats:italic>P<\/jats:italic>\u2009=\u20090.015 and <jats:italic>P<\/jats:italic>\u2009=\u20090.041, respectively), 2 hallmarks of the late NVC pattern. In multivariate analysis, profuse CT were independently associated with past or current digital ulcers (odds ratio [OR] 2.95 [95% confidence interval (95% CI) 1.09\u201319.63]), and pseudotumoral CT were independently associated with the late NVC pattern (OR 4.84 [95% CI 1.32\u201326.19]) and with precapillary pulmonary hypertension (OR 12.60 [95% CI 1.68\u201394.53]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrate that the number and size of CT are associated with the most severe NVC pattern. In addition, profuse and pseudotumoral CT identify a subset of patients with a more severe vascular phenotype. Further prospective studies should determine whether CT number and size could serve as an early clinical biomarker for the development of severe vascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22766","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T10:36:48Z","timestamp":1444991808000},"page":"1021-1027","source":"Crossref","is-referenced-by-count":36,"title":["Skin Telangiectasia and the Identification of a Subset of Systemic Sclerosis Patients With Severe Vascular Disease"],"prefix":"10.1002","volume":"68","author":[{"given":"Charlotte","family":"Hurabielle","sequence":"first","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Avouac","sequence":"additional","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Lepri","sequence":"additional","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullia","family":"de Risi","sequence":"additional","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kahan","sequence":"additional","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Allanore","sequence":"additional","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9, H\u00f4pital Cochin Paris 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