{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:57:14Z","timestamp":1793642234261,"version":"4.5.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008368","name":"Danish Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies. The study objective was in a controlled setting to describe cardiac abnormalities by noninvasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, 76 patients with PM\/DM and 48 matched healthy controls (HCs) were assessed by serum levels of cardiac troponin I, electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging, and quantitative cardiac <jats:sup>99m<\/jats:sup>Tc\u2010pyrophosphate (<jats:sup>99m<\/jats:sup>Tc\u2010PYP) scintigraphy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HCs, patients with PM\/DM more frequently had left ventricular diastolic dysfunction (LVDD) (12% versus 0%; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and longer QRS and QT intervals (<jats:italic>P<\/jats:italic>\u2009=\u20090.007 and <jats:italic>P<\/jats:italic> &lt; 0.0001, respectively). In multivariate analysis, factors associated with LVDD were age (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), disease duration (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), presence of myositis\u2010specific or \u2010associated autoantibodies (<jats:italic>P<\/jats:italic>\u2009=\u20090.05), and high cardiac <jats:sup>99m<\/jats:sup>Tc\u2010PYP uptake (<jats:italic>P<\/jats:italic>\u2009=\u20090.006). In multivariate analysis of the pooled data for patients and HCs, a diagnosis of PM\/DM (<jats:italic>P<\/jats:italic> &lt; 0.0001) was associated with LVDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with PM or DM had an increased prevalence of cardiac abnormalities compared to HCs. LVDD was a common occurrence in PM\/DM patients and correlated to disease duration. In addition, the association of LVDD with myositis\u2010specific or \u2010associated autoantibodies and high cardiac <jats:sup>99m<\/jats:sup>Tc\u2010PYP uptake supports the notion of underlying autoimmunity and myocardial inflammation in patients with PM\/DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22772","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T11:35:49Z","timestamp":1445859349000},"page":"1012-1020","source":"Crossref","is-referenced-by-count":58,"title":["Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities"],"prefix":"10.1002","volume":"68","author":[{"given":"L. P.","family":"Diederichsen","sequence":"first","affiliation":[{"name":"Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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