{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:19:14Z","timestamp":1771337954237,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore development of a screening test for rheumatoid arthritis (RA) patients most likely to develop radiographic damage in the next year. The test is a simple, objective measurement of elevated dermal temperature over an inflamed joint in this observational, prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seropositive RA patients were sequentially enrolled into cohorts with hot or cool joints, as determined by a dermal thermometer. Patients naive to biologic therapy were maintained on a stable dosage of methotrexate (20\u201325 mg\/week). The hot\u2010joint cohort had a joint skin temperature greater than their body temperature on vital signs. Hand\/wrist radiographs obtained at baseline and 1 year later were read and scored using modified Sharp\/van der Heijde scores (SHS) by a single reader without sequence order or identifiers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each cohort consisted of 104 patients enrolled into observation between 2009 and 2014. Patients in the cohort with hot joints had a mean\u2009\u00b1\u2009SD joint temperature of 1.06\u2009\u00b1\u20090.69\u00b0F above central body temperature and a nearly 4\u2010fold higher risk of new radiographic damage than those with cool joints (SHS score 8.7\u2009\u00b1\u20096.2 versus 2.5\u2009\u00b1\u20091.4; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Sensitivity and specificity for joint temperature to predict radiographic damage in the next year were 92% and 78%, respectively, in the hot\u2010joint cohort. As expected, this cohort at baseline was younger, had more recent onset RA, and had higher Westergren erythrocyte sedimentation rate levels than the cool\u2010joint cohort (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dermal joint temperature may become a screening test to quickly and accurately identify individual RA patients at high risk for radiographic damage and those who may benefit most from biologic therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22813","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T10:55:29Z","timestamp":1450090529000},"page":"1201-1205","source":"Crossref","is-referenced-by-count":9,"title":["Using Dermal Temperature to Identify Rheumatoid Arthritis Patients With Radiologic Progressive Disease in Less Than One Minute"],"prefix":"10.1002","volume":"68","author":[{"given":"Maria","family":"Greenwald","sequence":"first","affiliation":[{"name":"Desert Medical Advances Palm Desert California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann","family":"Ball","sequence":"additional","affiliation":[{"name":"Desert Medical Advances Palm Desert California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Guerrettaz","sequence":"additional","affiliation":[{"name":"Newport News Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Paulus","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34498"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21641"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080182"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21767"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20517"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38083"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.149765"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/9.7.461"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4037\/ajcc2007.16.5.485","article-title":"Accuracy and precision of noninvasive temperature measurement in adult intensive care","volume":"16","author":"Lawson L","year":"2007","journal-title":"Am J Crit Care"},{"key":"e_1_2_4_13_1","first-page":"261","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"27","author":"Heijde DM.","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_4_14_1","first-page":"731","article-title":"Smallest detectable difference in radiological progression","volume":"26","author":"Lassere M","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_4_15_1","first-page":"904","article-title":"Minimal clinically important difference in radiological progression of joint damage over 1 year in rheumatoid arthritis: preliminary results of a validation study with clinical experts","volume":"28","author":"Bruynesteyn K","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136982"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33455"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1854::AID-ANR9>3.0.CO;2-F"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22719"}],"container-title":["Arthritis Care &amp; 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