{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:33:50Z","timestamp":1790804030655,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#HHSN26S201300057C"],"award-info":[{"award-number":["#HHSN26S201300057C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AG043501"],"award-info":[{"award-number":["K01AG043501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NO1\u2010DE\u201032636"],"award-info":[{"award-number":["NO1\u2010DE\u201032636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE12354\u201015A1"],"award-info":[{"award-number":["R01 DE12354\u201015A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Anticentromere antibodies (ACAs) define a subset of primary Sj\u00f6gren's syndrome (SS) with a unique phenotype, including features of limited cutaneous systemic sclerosis and a lower frequency of anti\u2010SSA\/SSB antibodies. We sought to determine whether ACAs are associated with more severe exocrine glandular dysfunction in a large cohort of primary SS subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional analysis of 1,361 subjects with primary SS from the Sj\u00f6gren's International Collaborative Clinical Alliance Registry, stratified by the presence or absence of ACAs. ACAs were assayed by immunofluorescence staining on HEp\u20102 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ACAs were present in 82 of the 1,361 SS subjects (6%) and were associated with older age, female sex, and lower frequencies of anti\u2010SSA\/SSB, rheumatoid factor, and hyperglobulinemia. Among ACA\u2010positive versus ACA\u2010negative subjects, there was a higher frequency of a focus score \u22652 (71% versus 53%; <jats:italic>P<\/jats:italic>\u2009=\u20090.002), a higher median focus score (2.8 versus 2.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.0440), and greater exocrine gland dysfunction: Schirmer's test value: median 4 versus 5 mm\/5 minutes; <jats:italic>P<\/jats:italic>\u2009=\u20090.0003, and unstimulated whole saliva (UWS) flow rate: median 0.08 versus 0.37 ml\/5 minutes; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001. ACA\u2010positive subjects had an increased risk of UWS &lt;0.1 ml\/minute (odds ratio [OR] 12.24 [95% confidence interval (95% CI) 4.91\u201341.02]) and Schirmer's test value &lt;5 mm\/5 minutes (OR 2.52 [95% CI 1.50\u20134.36]) after correcting for age, sex, anti\u2010SSA\/SSB, and focus score. Labial gland fibrosis was not different between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a large international registry of SS, ACA had an independent association with more severe exocrine glandular dysfunction. This dysfunction was associated with more pronounced labial salivary glandular inflammation but not fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22859","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T09:18:14Z","timestamp":1455182294000},"page":"1554-1559","source":"Crossref","is-referenced-by-count":50,"title":["Association of Anticentromere Antibodies With More Severe Exocrine Glandular Dysfunction in Sj\u00f6gren's Syndrome: Analysis of the Sj\u00f6gren's International Collaborative Clinical Alliance Cohort"],"prefix":"10.1002","volume":"68","author":[{"given":"Alan N.","family":"Baer","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Medrano","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"McAdams\u2010DeMarco","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Gniadek","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2005-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2958"},{"key":"e_1_2_6_4_1","first-page":"2253","article-title":"Anticentromere antibodies identify patients with Sj\u00f6gren's syndrome and autoimmune overlap syndrome","volume":"34","author":"Salliot C","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_1","first-page":"272","article-title":"Overlap of ACA\u2010positive systemic sclerosis and Sj\u00f6gren's syndrome: a distinct clinical entity with mild organ involvement but at high risk of lymphoma","volume":"31","author":"Baldini C","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-140"},{"key":"e_1_2_6_7_1","first-page":"2238","article-title":"Clinical and laboratory features of anticentromere antibody positive primary Sj\u00f6gren's syndrome","volume":"28","author":"Katano K","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30381"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.06.041"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.09.025"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1789-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260408"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22859","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:17:02Z","timestamp":1759421822000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,16]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/acr.22859"],"URL":"https:\/\/doi.org\/10.1002\/acr.22859","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,16]]}}}