{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:37:40Z","timestamp":1761896260977,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the acceptable level of positive predictive value (PPV) and negative predictive value (NPV) for classification criteria for gout, given the type of study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an international web\u2010based survey with 91 general practitioners and rheumatologists experienced in gout. Conjoint analysis was used as the framework for designing and analyzing pairs of 2 profiles, each describing a study type, a PPV, and an NPV. There were 5 study types presented: a phase III randomized controlled trial (RCT) of a nonsteroidal antiinflammatory drug versus prednisone for acute gout flares, a phase III RCT of a biologic agent for acute gout flares, a phase II RCT of a novel uricosuric drug of unknown efficacy and limited toxicity data, a case\u2013control, genome\u2010wide association study of gout, and a cohort study examining long\u2010term outcomes of gout. PPV and NPV both had 5 levels ranging from 60\u201399%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The panelists in majority were male (65%) rheumatologists (93%) with an average of 19 years of practice, seeing 5 to 60 gout patients monthly. PPV was most highly weighted in decision making: the relative importance was 59% for PPV, 29% for NPV, and 13% for study type. The preferred PPV was 90% or 80%, with an accompanying NPV of 70% or 80%, dependent on study type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preferred PPVs and NPVs range between 70% and 90% and differ by study type. A single cut point can be a reasonable approach for all study types if a PPV of 90% and NPV of 80% is approximated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22875","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T02:39:36Z","timestamp":1457231976000},"page":"1731-1735","source":"Crossref","is-referenced-by-count":3,"title":["What Should Be the Cut Point for Classification Criteria of Studies in Gout? A Conjoint Analysis"],"prefix":"10.1002","volume":"68","author":[{"given":"Jaap","family":"Fransen","sequence":"first","affiliation":[{"name":"Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wietske","family":"Kievit","sequence":"additional","affiliation":[{"name":"Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University Schools of Medicine and of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Schumacher","sequence":"additional","affiliation":[{"name":"University of Pennsylvania and VA Medical Center Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Jansen","sequence":"additional","affiliation":[{"name":"Vie Curi Medical Centre Venlo, Venlo, and Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-8479","authenticated-orcid":false,"given":"William J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Otago Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1002\/art.39254"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1002\/art.27584"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1002\/art.38098"},{"volume-title":"Sample size issues for conjoint analysis studies: Sawtooth Software research paper series","year":"1998","author":"Orme B.","key":"e_1_2_5_5_1"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1093\/rheumatology\/ket154"},{"key":"e_1_2_5_7_1","first-page":"781","article-title":"The modern scientific physician: 3. 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