{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:47:21Z","timestamp":1790624841295,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"the National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["(AR-055899)"],"award-info":[{"award-number":["(AR-055899)"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify novel combinations of genetic and psychological factors that predicted 12\u2010month postoperative pain and disability outcomes following arthroscopic shoulder surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective presurgical cohort (n\u2009=\u2009150) was recruited to complete validated psychological questionnaires and have their DNA collected from saliva. DNA was genotyped for a priori selected genes involved with pain modulation (<jats:italic>ADRB2<\/jats:italic>, <jats:italic>OPRM1<\/jats:italic>, <jats:italic>AVPR1A<\/jats:italic>, <jats:italic>GCH1<\/jats:italic>, and <jats:italic>KCNS1<\/jats:italic>) and inflammation (<jats:italic>IL1B<\/jats:italic>, <jats:italic>TNF\/LTA<\/jats:italic>, and <jats:italic>IL6<\/jats:italic>). The outcome measures of interest were the Brief Pain Inventory and Disabilities of the Arm, Shoulder, and Hand questionnaire. Followup for the cohort was at 3, 6, and 12 months postoperatively. After controlling for age, sex, race, and preoperative status, genetic and psychological factors were entered as main effects and interaction terms in separate general linear models for predicting postoperative pain and disability outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven interactions involving pain\u2010modulatory genes were identified. Three provided strong statistical evidence for different outcomes, including <jats:italic>KCNS1<\/jats:italic> and kinesiophobia for preoperative pain intensity, <jats:italic>ADRB2<\/jats:italic> and depressive symptoms for postoperative course, and <jats:italic>GCH1<\/jats:italic> and anxiety symptoms for 12\u2010month pain\u2010intensity outcome. Ten interactions involving inflammatory genes were identified. Three provided strong statistical evidence for the 12\u2010month postoperative course outcome, including 2 different <jats:italic>IL6<\/jats:italic> single\u2010nucleotide polymorphism and pain catastrophizing, and <jats:italic>IL6<\/jats:italic> and depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study identified novel genetic and psychological interactions that can be used in future studies to further understand the development of persistent postoperative pain and investigate the effectiveness of tailored treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22876","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T02:39:36Z","timestamp":1457231976000},"page":"1671-1680","source":"Crossref","is-referenced-by-count":24,"title":["Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve\u2010Month Postoperative Pain and Disability Outcomes"],"prefix":"10.1002","volume":"68","author":[{"given":"Steven Z.","family":"George","sequence":"first","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Wallace","sequence":"additional","affiliation":[{"name":"University of Florida Genetics Institute, University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Moser","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin 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