{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:50:36Z","timestamp":1759452636987,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether HLA\u2013B27 testing and imaging of the sacroiliac joints are needed in patients with \u22641 spondyloarthritis (SpA) feature, referred to a secondary care setting, after medical history collection, clinical examination, and measurement of acute phase reactants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline data from patients in the Spondyloarthritis Caught Early (SPACE) cohort visiting the rheumatology outpatient clinic of 5 centers across Europe (with back pain \u22653 months, \u22642 years, onset at ages &lt;45 years) were used. All patients underwent a full diagnostic work\u2010up: magnetic resonance imaging (MRI) and radiographs of the sacroiliac joints, HLA\u2013B27 testing, and assessment of all other SpA features. Patients were diagnosed according to the treating rheumatologist and classified according to the Assessment of SpondyloArthritis international Society (ASAS) axial SpA criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 354 patients, 133 (37.5%) showed 0 or 1 SpA feature after medical history collection, physical examination, and measurement of acute phase reactants (38 without SpA features, 95 with 1 SpA feature). Of the patients with \u22641 SpA feature, 18.4% (with 0 SpA features) and 17.9% (with 1 SpA feature) were diagnosed with axial SpA according to the rheumatologist after additional investigations (HLA\u2013B27 testing and sacroiliac joint imaging). Additionally, 4 of 38 patients (10.5%) without SpA features fulfilled the ASAS axial SpA criteria (all according to the imaging arm only: 2 as MRI+\/modified New York criteria (mNY)+, 1 as MRI+\/mNY\u2212, and 1 as MRI\u2212\/mNY+). Of the 95 patients with 1 SpA feature, 22 (23.2%) fulfilled the ASAS axial SpA criteria (all according to the imaging arm only: 3 as MRI+\/mNY+, 15 as MRI+\/mNY\u2212, and 4 as MRI\u2212\/mNY+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In these patients in a secondary care setting with \u22641 SpA feature, axial SpA could not be ruled out without sacroiliac joint imaging and\/or HLA\u2013B27 testing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22883","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T03:24:56Z","timestamp":1458357896000},"page":"1726-1730","source":"Crossref","is-referenced-by-count":6,"title":["Are Additional Tests Needed to Rule Out Axial Spondyloarthritis in Patients Ages 16\u201345 Years With Short\u2010Duration Chronic Back Pain and Maximally One Spondyloarthritis Feature?"],"prefix":"10.1002","volume":"68","author":[{"given":"P. A. C.","family":"Bakker","sequence":"first","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Ez\u2010Zaitouni","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Lunteren","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"De Hooge","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Fagerli","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Amsterdam Medical Center, Amsterdam, and Atrium Medical Center Heerlen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Oosterhout","sequence":"additional","affiliation":[{"name":"Groene Hart Ziekenhuis Gouda The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ramonda","sequence":"additional","affiliation":[{"name":"DIMED, University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reijnierse","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"van der Heijde","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A.","family":"van Gaalen","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(02)00372-x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204231"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203201"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203460"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev267"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.02.008"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.33"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.011247"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20990"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201884"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket164"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39225"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110767"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22883","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:22:20Z","timestamp":1759425740000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/acr.22883"],"URL":"https:\/\/doi.org\/10.1002\/acr.22883","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2016,10,6]]}}}