{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:34:40Z","timestamp":1790109280669,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG\u201018832, AR\u2010048939, and AR\u2010055533"],"award-info":[{"award-number":["AG\u201018832, AR\u2010048939, and AR\u2010055533"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether medial tibiofemoral joint space width (JSW) on 3\u2010dimensional (3\u2010D) standing computed tomography (SCT) correlates more closely with magnetic resonance imaging cartilage morphology (CM) and meniscal scores than does radiographic 2\u2010D JSW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants in the Multicenter Osteoarthritis Study, who had standing fixed\u2010flexion posteroanterior knee radiographs, were recruited. Medial tibiofemoral 3\u2010D JSW on SCT and 2\u2010D JSW on fixed\u2010flexion radiographs were compared with medial tibiofemoral cartilage and meniscal morphology using the Whole\u2010Organ Magnetic Resonance Imaging Score (WORMS). Associations between the area of the articular surface with 3\u2010D JSW &lt;2.5 mm on SCT, radiographic minimal 2\u2010D JSW, and the WORMS\u2010CM and meniscal scores were assessed using Spearman's rho.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the 19 participants included (33 knees), mean\u2009\u00b1\u2009SD age was 66.9\u2009\u00b1\u20095.4 years, body mass index was 29.5\u2009\u00b1\u20094.4 kg\/m<jats:sup>2<\/jats:sup>, 42.1% of participants were female, and the Kellgren\/Lawrence grades were 0 (21.2%), 1 (36.4%), 2 (18.2%), and 3 (24.2%). The articular surface area with 3\u2010D JSW &lt;2.5 mm on SCT correlated with WORMS\u2010CM scores for the central medial tibia (r<jats:sub>s<\/jats:sub>\u2009=\u20090.84, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), central medial femur (r<jats:sub>s<\/jats:sub>\u2009=\u20090.60, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.007), and posterior medial meniscal tear (r<jats:sub>s<\/jats:sub>\u2009=\u20090.39, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.026), as did other cut points for 3\u2010D JSW. Correlations with radiographic minimal 2\u2010D JSW were \u22120.66, \u22120.52, and \u22120.40, respectively, differing from SCT only for tibial cartilage (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Greater surface area with a low JSW, measured by SCT, correlates more strongly with the severity of tibial cartilage lesions, while correlating with medial femoral cartilage and meniscal damage to a similar extent as radiographic minimal JSW. SCT may enable valid stratification of participants in clinical trials, through quickly and inexpensively characterizing osteoarthritis features.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22888","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T03:25:19Z","timestamp":1458357919000},"page":"1410-1416","source":"Crossref","is-referenced-by-count":42,"title":["Correlations of Medial Joint Space Width on Fixed\u2010Flexed Standing Computed Tomography and Radiographs With Cartilage and Meniscal Morphology on Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"68","author":[{"given":"N. A.","family":"Segal","sequence":"first","affiliation":[{"name":"University of Kansas, Kansas City, and University of Iowa Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Frick","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Duryea","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Roemer","sequence":"additional","affiliation":[{"name":"Boston University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Nevitt","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Torner","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. T.","family":"Felson","sequence":"additional","affiliation":[{"name":"Boston University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Food and Drug Administration. Clinical development programs for human drugs biological products and medical devices for the treatment and prevention of osteoarthritis.1999. 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