{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:43:18Z","timestamp":1787679798525,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute Carlos III","award":["FIS project PI13\/02034"],"award-info":[{"award-number":["FIS project PI13\/02034"]}]},{"name":"Fondos FEDER"},{"DOI":"10.13039\/501100013298","name":"Spanish Society of Rheumatology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013298","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe health\u2010related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study drawing upon baseline data of axial SpA patients (Assessment of SpondyloArthritis international Society criteria) from the ESPERANZA cohort. Linear regression analyses were used to evaluate the associations between disease activity and radiographic damage (spine and sacroiliac joints) with HRQOL, physical function, and spinal mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 259 patients were included. The mean\u2009\u00b1\u2009SD age was 32.2\u2009\u00b1\u20096.9 years, disease duration was 13.3\u2009\u00b1\u20096.8 months, Ankylosing Spondylitis Quality of Life score was 5.9\u2009\u00b1\u20094.8, Bath Ankylosing Spondylitis Functional Index score was 2.4\u2009\u00b1\u20092.3, Bath Ankylosing Spondylitis Metrology Index score was 1.4\u2009\u00b1\u20091.3, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was 3.8\u2009\u00b1\u20092.3, C\u2010reactive protein (CRP) level was 9.7\u2009\u00b1\u200913.2 mg\/liter, and Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI\u2010s) score was 1.7\u2009\u00b1\u20091.6. HRQOL was mainly associated with disease activity on univariate analysis (\u03b2 values for BASDAI 0.646, patient global visual analog scale [VAS] 0.641, night back pain VAS 0.598, physician VAS 0.560, and CRP level 0.275; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 for all), whereas the association with radiographic damage was weaker (standardized \u03b2 for BASRI\u2010s 0.142; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). On multivariate models, HRQOL only remained significantly associated with disease activity (standardized \u03b2 for BASDAI 0.330; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, and physician VAS 0.205 and night back pain VAS 0.210; <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Similarly, physical function was associated with disease activity and radiographic damage on univariate analysis, but only with disease activity (BASDAI \u03b2 0.466; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) on multivariate analysis. However, spinal mobility was associated with radiographic damage in both univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with axial SpA already have impaired quality of life and physical function, albeit mildly, at the beginning of their disease course. Both outcomes are mainly associated with disease activity in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22908","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T20:17:37Z","timestamp":1461615457000},"page":"150-155","source":"Crossref","is-referenced-by-count":31,"title":["Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis"],"prefix":"10.1002","volume":"69","author":[{"given":"Cristina","family":"Fern\u00e1ndez\u2010Carballido","sequence":"first","affiliation":[{"name":"Hospital General Universitario de Elda Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Navarro\u2010Comp\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz (IdiPaz) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Castillo\u2010Gallego","sequence":"additional","affiliation":[{"name":"Hospital Torrec\u00e1rdenas Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Castro\u2010Villegas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda\/IMIBIC\/Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Collantes\u2010Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda\/IMIBIC\/Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"de Miguel","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz (IdiPaz) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Esperanza Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150037"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem296"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11197"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091793"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.766"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.141200"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_4_9_1","first-page":"372","article-title":"La versi\u00f3n espa\u00f1ola del BASDAI es fiable y se correlaciona con la actividad de la enfermedad en pacientes con espondilitis anquilosante","volume":"31","author":"Ariza\u2010Ariza R","year":"2004","journal-title":"Rev Esp Reumatol"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2263::AID-ART23>3.0.CO;2-I"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1699-258X(06)73024-8"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.074724"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204262"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket164"},{"key":"e_1_2_4_16_1","first-page":"1:110","article-title":"The changing clinical picture and epidemiology of spondyloarthritis","author":"Tubergen A.","year":"2015","journal-title":"Nat Rev Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:21:40Z","timestamp":1759414900000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,21]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/acr.22908"],"URL":"https:\/\/doi.org\/10.1002\/acr.22908","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,21]]}}}