{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:51:18Z","timestamp":1770547878917,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010000004"],"award-info":[{"award-number":["UL1\u2010TR\u2010000004"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P60\u2010AR\u2010053308"],"award-info":[{"award-number":["P60\u2010AR\u2010053308"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Little data exist regarding mortality in ankylosing spondylitis (AS). We assessed diagnoses associated with in\u2010hospital mortality in AS using a population\u2010based inpatient data set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were abstracted from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample between 2007 and 2011. We identified AS admissions using International Classification of Diseases, Ninth Revision, Clinical Modification code 720.0. In\u2010hospital mortality was the primary outcome. Logistic regression was used to evaluate the association between top diagnoses and in\u2010hospital mortality. We performed a secondary analysis from the same years in all patients (with and without AS) with cervical spine (C\u2010spine) fracture to determine whether AS was an independent risk factor for mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2007 and 2011, we identified 12,484 admissions and 267 deaths in AS patients. C\u2010spine fracture with spinal cord injury and sepsis had the highest odds of death, with odds ratios (ORs) of 13.43 (95% confidence interval [95% CI] 8.00\u201322.55, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and 7.63 (95% CI 5.62\u201310.36, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), respectively. In the same time period, there were 53,606 C\u2010spine fracture admissions, of which 408 were coded with AS. Among all C\u2010spine fracture hospitalizations, an AS diagnosis was associated with inpatient death (OR 1.61 [95% CI 1.16\u20132.22], <jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In AS patients admitted to the hospital, C\u2010spine fracture is a leading cause of in\u2010hospital mortality. Other diagnoses associated with mortality include sepsis, pneumonia, cardiovascular disease, and comorbid illnesses. Among all hospitalizations with C\u2010spine fracture, AS was associated with increased odds of death. C\u2010spine fracture\u2013associated mortality warrants further study to elucidate risk factors in order to prevent such devastating fractures in AS patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22934","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T15:54:23Z","timestamp":1462809263000},"page":"271-277","source":"Crossref","is-referenced-by-count":29,"title":["Cervical Spinal Fracture and Other Diagnoses Associated With Mortality in Hospitalized Ankylosing Spondylitis Patients"],"prefix":"10.1002","volume":"69","author":[{"given":"Katherine D.","family":"Wysham","sequence":"first","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara G.","family":"Murray","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Hills","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Yelin","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianne S.","family":"Gensler","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910590307"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30277"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.3.174"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151191"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197709152971103"},{"key":"e_1_2_7_7_1","first-page":"86","article-title":"Survival among patients with ankylosing spondylitis: a life\u2010table analysis","volume":"8","author":"Khan MA","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230110"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207688"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2470"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-004-0556-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0764-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.185"},{"key":"e_1_2_7_14_1","unstructured":"HCUPnet: Healthcare Cost and Utilization Project. 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