{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:09:20Z","timestamp":1783764560107,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(81170244 and 81170090)"],"award-info":[{"award-number":["(81170244 and 81170090)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test whether prenatal exposure to earthquake (as a surrogate for acute prenatal stress) could have unfavorable effects on uric acid levels later in life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 536 individuals who had been prenatally exposed to the Tangshan earthquake in 1976, and 536 sex\u2010 and age\u2010matched individuals without that exposure. Serum uric acid concentrations were measured based on fasting blood samples, which were repeatedly collected in 2006, 2008, and 2010. Mean uric acid concentrations in 2010 and the increasing rate from 2006 to 2010 were compared between the 2 groups, after adjustment for age, sex, body mass index, serum concentrations of glucose, triglycerides, C\u2010reactive protein level, estimated glomerular filtration rate, and other potential confounders. We also used multiple logistic regression to estimate the risk of hyperuricemia (&gt;416 \u03bcmole\/liter in men or &gt;357 \u03bcmole\/liter in women) in 2010 by calculating the odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjustment for the previously mentioned covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with prenatal exposure to the earthquake had higher concentrations of serum uric acid (adjusted means 315 \u03bcmole\/liter versus 296 \u03bcmole\/liter; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and a higher likelihood of having hyperuricemia (multivariate adjusted OR 1.70 [95% CI 1.09\u20132.66]) in 2010 relative to those without the exposure. Prenatal exposure to the earthquake was consistently significantly associated with a faster increase in uric acid concentration from 2006 to 2010 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal exposure to the earthquake was associated with higher serum uric acid and higher odds of hyperuricemia in early adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22973","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T13:12:44Z","timestamp":1469452364000},"page":"703-708","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal Earthquake Exposure and Midlife Uric Acid Levels Among Chinese Adults"],"prefix":"10.1002","volume":"69","author":[{"given":"Chunpeng","family":"Ji","sequence":"first","affiliation":[{"name":"Hebei United University Kailuan General Hospital Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[{"name":"Harvard School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liufu","family":"Cui","sequence":"additional","affiliation":[{"name":"Hebei United University Kailuan General Hospital Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Cai","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Shi","sequence":"additional","affiliation":[{"name":"Hebei United University Kailuan General Hospital Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feon W.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Pennsylvania State University State College Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei United University Kailuan General Hospital Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Curhan","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Hebei United University Kailuan General Hospital Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Pennsylvania State University State College Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110864"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114259"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-347"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199703000-00001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000198544.09909.1a"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074634"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11430-011-4218-x"},{"key":"e_1_2_6_9_1","first-page":"18","article-title":"Research on distribution of disasters in Tangshan earthquake","volume":"26","author":"Su YP","year":"2006","journal-title":"Earthq Eng Eng Vibration (China)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.01.030"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2741\/3950"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2012.07.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070107"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590051663.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.06.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00053.2003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000049763.51269.51"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042408"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00481.2006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00201.2003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221716.55088.d4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22083"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056864"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-419"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074691"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22973","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22973","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:02:56Z","timestamp":1759424576000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/acr.22973"],"URL":"https:\/\/doi.org\/10.1002\/acr.22973","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]}}}