{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:15:30Z","timestamp":1759421730606,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5\u2010R21\u2010AR\u2010059931\u201002"],"award-info":[{"award-number":["5\u2010R21\u2010AR\u2010059931\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We have previously reported increased long\u2010term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox proportional hazards models were used to calculate hazard ratios (HRs) of death from all causes among children exposed to parental RA, compared to unexposed children. Risk of death after infection or respiratory diseases was also assessed for children below the age of 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study followed 1,917,723 newborns for an average of 16 years. Of these, 13,556 were exposed to maternal RA and 6,330 to paternal RA. Overall mortality rates in children exposed to maternal or paternal RA did not differ from those in unexposed children (HR 0.98 [95% confidence interval (95% CI) 0.84\u20131.15] and 1.08 [95% CI 0.86\u20131.36], respectively), nor did the risk of death below the ages of 5 years, 3 years, or 1 year. In the group of children below the age of 5 years, 6,106 children of parents with RA were diagnosed with respiratory diseases and 3,320 with infectious diseases. The case fatality rate in children with these diseases was not significantly higher than in unexposed children (HR 1.11 [95% CI 0.74\u20131.66] and 0.84 [95% CI 0.52\u20131.35], respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children of parents with RA had similar mortality rates as other children, as well as after diagnoses of respiratory or infectious diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22991","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T11:18:50Z","timestamp":1467890330000},"page":"933-937","source":"Crossref","is-referenced-by-count":0,"title":["Parental Rheumatoid Arthritis, Child Mortality, and Case Fatality: A Nationwide Cohort Study"],"prefix":"10.1002","volume":"69","author":[{"given":"Ane L.","family":"Rom","sequence":"first","affiliation":[{"name":"The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun S.","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Aarhus, Aarhus, Denmark, and Institute of Clinical Research, University of Southern Denmark, and Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"University of Aarhus, Aarhus, Denmark, and University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damini","family":"Jawaheer","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete L.","family":"Hetland","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, and University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bent","family":"Ottesen","sequence":"additional","affiliation":[{"name":"The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina S.","family":"M\u00f8rch","sequence":"additional","affiliation":[{"name":"The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, and Danish Cancer Society Research Centre Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38874"},{"key":"e_1_2_3_4_1","first-page":"9","article-title":"High rate of preterm birth in pregnancies complicated by rheumatoid arthritis","volume":"31","author":"Langen ES","year":"2014","journal-title":"Am J Perinatol"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12324"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1427-3"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38519"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.761"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1426"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208072"},{"key":"e_1_2_3_11_1","first-page":"320","article-title":"The Danish medical birth registry","volume":"45","author":"Knudsen LB","year":"1998","journal-title":"Dan Med Bull"},{"key":"e_1_2_3_12_1","first-page":"441","article-title":"The Danish civil registration system: a cohort of eight million persons","volume":"53","author":"Pedersen CB","year":"2006","journal-title":"Dan Med Bull"},{"key":"e_1_2_3_13_1","first-page":"263","article-title":"The Danish national hospital register: a valuable source of data for modern health sciences","volume":"46","author":"Andersen TF","year":"1999","journal-title":"Dan Med Bull"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm324"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.01.026"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24328"}],"container-title":["Arthritis Care &amp; 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