{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:43:48Z","timestamp":1791639828698,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["18769"],"award-info":[{"award-number":["18769"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent findings suggest that \u03b2\u2010adrenergic blockers have antinociceptive properties. The aim of this study was to compare levels of large\u2010joint pain between those taking adrenergic blockers and those taking other antihypertensive medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Genetics of Osteoarthritis and Lifestyle (GOAL) study, a secondary\u2010care cohort of osteoarthritis (OA) patients, were used. Joint pain was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores in 873 individuals with symptomatic hip and\/or knee OA and hypertension, who were taking \u22651 prescription antihypertensive medications. The association between adrenergic blocker prescription and at least moderate joint pain (WOMAC score &lt;75) and use of prescription analgesics was examined using binary logistic regression. Analyses were adjusted for age, sex, body mass index, knee or hip OA, history of joint replacement (at other joints), anxiety, and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of \u03b2\u2010adrenergic blockers was associated with lower WOMAC pain scores and with a lower prevalence of joint pain after adjustment for demographic variables and comorbidity (adjusted odds ratio [OR<jats:sub>adj<\/jats:sub>] for pain 0.68 [95% confidence interval (95% CI) 0.51, 0.92]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.011). No associations with pain were observed with use of alpha\u2010blockers (OR<jats:sub>adj<\/jats:sub> for pain 0.94 [95% CI 0.55, 1.58]) or with any other class of antihypertensive medications. Prescription of beta\u2010blockers was also associated negatively with opioid use (OR<jats:sub>adj<\/jats:sub> for opioids 0.73 [95% CI 0.54, 0.98]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.037) and with the use of prescription analgesics in general (OR<jats:sub>adj<\/jats:sub> for analgesics 0.74 [95% CI 0.56, 0.94]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of beta\u2010blockers is associated with less joint pain and a lower use of opioids and other analgesics in individuals with symptomatic large\u2010joint OA. This observation needs to be confirmed by other studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23091","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T09:00:19Z","timestamp":1475830819000},"page":"1076-1081","source":"Crossref","is-referenced-by-count":55,"title":["Association of Beta\u2010Blocker Use With Less Prevalent Joint Pain and Lower Opioid Requirement in People With Osteoarthritis"],"prefix":"10.1002","volume":"69","author":[{"given":"Ana M.","family":"Valdes","sequence":"first","affiliation":[{"name":"University of Nottingham, Nottingham City Hospital, and Arthritis Research UK Pain Centre Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Abhishek","sequence":"additional","affiliation":[{"name":"University of Nottingham, Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Muir","sequence":"additional","affiliation":[{"name":"University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Nottingham, Nottingham City Hospital, and Arthritis Research UK Pain Centre Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose A.","family":"Maciewicz","sequence":"additional","affiliation":[{"name":"AstraZeneca Research &amp; Development Cambridge Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[{"name":"University of Nottingham, Nottingham City Hospital, and Arthritis Research UK Pain Centre Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X10376120"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903496422"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.137583"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18198"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.09.004"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.12.006"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27574"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115687"},{"key":"e_1_2_4_11_1","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.11.023"},{"key":"e_1_2_4_13_1","first-page":"549","article-title":"Beta\u2010blockers: friend or foe in asthma?","volume":"6","author":"Arboe B","year":"2013","journal-title":"Int J Gen Med"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4891"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:57:56Z","timestamp":1759420676000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/acr.23091"],"URL":"https:\/\/doi.org\/10.1002\/acr.23091","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]}}}