{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:26:10Z","timestamp":1763328370747,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["N01\u2010AI\u201015416"],"award-info":[{"award-number":["N01\u2010AI\u201015416"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24\u2010AR\u201002224"],"award-info":[{"award-number":["K24\u2010AR\u201002224"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23\u2010AR\u2010052820","K24\u2010AR\u2010049185"],"award-info":[{"award-number":["K23\u2010AR\u2010052820","K24\u2010AR\u2010049185"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated the relationships between glucocorticoid use, disease activity, and changes in body mass index (BMI) in patients with antineutrophil cytoplasmic antibody\u2013associated vasculitis (AAV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed AAV patients enrolled in the Rituximab in AAV trial. Glucocorticoid use, BMI, and disease activity were measured regularly during the trial period. We performed mixed\u2010effects regressions to examine the associations of time\u2010dependent cumulative average glucocorticoid use and disease activity with changes in BMI over time, while adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean\u2009\u00b1\u2009SD baseline BMI of the 197 patients enrolled was 28.8\u2009\u00b1\u20096.3 kg\/m<jats:sup>2<\/jats:sup>. Patients with newly diagnosed AAV tended to have a lower mean\u2009\u00b1\u2009SD BMI than those with relapsing disease (28.0\u2009\u00b1\u20095.7 kg\/m<jats:sup>2<\/jats:sup> versus 29.6\u2009\u00b1\u20096.8 kg\/m<jats:sup>2<\/jats:sup>) and higher disease activity (mean\u2009\u00b1\u2009SD Birmingham Vasculitis Activity Score for Wegener's Granulomatosis 8.7\u2009\u00b1\u20093.3 versus 7.4\u2009\u00b1\u20092.7). The most significant change in BMI occurred during the first 6 months of the trial (mean\u2009\u00b1\u2009SD increase of 1.1\u2009\u00b1\u20092.2 kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Disease activity improvement, glucocorticoid exposure, and randomization to rituximab were each independently associated with an increase in BMI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for all analyses).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that changes in BMI, as well as glucocorticoid exposure, are independently associated with improvements in disease activity in AAV. Rituximab may also have effects on BMI independent of its impact on disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23099","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T08:59:47Z","timestamp":1475830787000},"page":"1004-1010","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Disease Activity, Glucocorticoid Exposure, and Rituximab on Body Composition During Induction Treatment of Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis"],"prefix":"10.1002","volume":"69","author":[{"given":"Zachary S.","family":"Wallace","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli M.","family":"Miloslavsky","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cascino","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian H.","family":"Unizony","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Lu","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cees G. M.","family":"Kallenberg","sequence":"additional","affiliation":[{"name":"Universiteit Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Langford","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Merkel","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Monach","sequence":"additional","affiliation":[{"name":"Boston Medical Center, Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Seo","sequence":"additional","affiliation":[{"name":"Johns Hopkins Vasculitis Center, Johns Hopkins University Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Spiera","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. William","family":"St.Clair","sequence":"additional","affiliation":[{"name":"Duke University Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Specks","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Brunetta","sequence":"additional","affiliation":[{"name":"Genentech San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyon K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Stone","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014090903"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21984"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665115000117"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23561"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213277"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic. 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