{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:27:57Z","timestamp":1792063677468,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR\u2010050026"],"award-info":[{"award-number":["AR\u2010050026"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR\u2010050026\u201008S1"],"award-info":[{"award-number":["AR\u2010050026\u201008S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Citrullinated proteins have been found within atherosclerotic plaque. However, studies evaluating the association between anti\u2013citrullinated protein antibodies (ACPAs) and imaging measures of atherosclerosis in patients with rheumatoid arthritis (RA) have been limited to seroreactive citrullinated fibrinogen or citrullinated vimentin and have rendered contradictory results. Therefore, our objective was to evaluate this association using an extended panel of ACPAs in a larger sample of RA patients without clinical cardiovascular disease (CVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ACPAs were identified using a custom Bio\u2010Plex bead assay in 270 patients from 2 independent RA cohorts without clinical CVD, with the first one consisting of 195 patients and the other of 75 patients. Coronary artery calcium (CAC) was assessed by computed tomography as a measure of coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High levels of anti\u2013citrullinated histone H2B antibodies were strongly associated with higher CAC scores, compared with lower antibody levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.001); this remained significant after adjustment for traditional CV and RA\u2010specific risk factors (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). No association between levels of ACPAs and CAC progression at 3 years was seen (<jats:italic>P<\/jats:italic>\u2009=\u20090.09); however, the number of progressors was small (n\u2009=\u200992).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher levels of ACPAs targeting Cit\u2010histone H2B were associated with higher CAC scores when compared to lower antibody levels, suggesting a potential role for histone citrullination seroreactivity in atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23106","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T09:01:35Z","timestamp":1475830895000},"page":"1276-1281","source":"Crossref","is-referenced-by-count":33,"title":["Association of Anti\u2013Citrullinated Peptide Antibodies With Coronary Artery Calcification in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"69","author":[{"given":"Laura","family":"Geraldino\u2010Pardilla","sequence":"first","affiliation":[{"name":"Columbia University College of Physicians &amp; Surgeons New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon T.","family":"Giles","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians &amp; Surgeons New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Sokolove","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine and VA Palo Alto Health Care System Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Zartoshti","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians &amp; Surgeons New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine and VA Palo Alto Health Care System Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor\u2013University of California Los Angeles Medical Center Torrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Detrano","sequence":"additional","affiliation":[{"name":"University of California Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabahat","family":"Bokhari","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians &amp; Surgeons New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Bathon","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians &amp; Surgeons New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054612.26458.B2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8251-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37961"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39302"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101143"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4314"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39419"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072100"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev027"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38307"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009884"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301627"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39283"}],"container-title":["Arthritis Care &amp; 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