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Improved\/high function in 2\u2010year gait speed and patient\u2010reported outcomes (PROs) were based on improving or remaining in the best (i.e., maintaining high) function quintile compared to baseline status. Optimal thresholds predicting improved\/high function were investigated using classification trees for the legacy federal guideline metric requiring 150 minutes\/week of moderate\u2010vigorous (MV) activity in bouts lasting 10 minutes or more (MV\u2010bout) and other metrics (total MV, sedentary, light intensity activity, nonsedentary minutes\/week).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Optimal thresholds based on total MV minutes\/week predicted improved\/high function outcomes more strongly than the legacy or other investigated metrics. Meeting the 45 total MV minutes\/week threshold had increased relative risk (RR) for improved\/high function (gait speed RR 1.8, 95% confidence interval [95% CI] 1.6, 2.1 and PRO physical function RR 1.4, 95% CI 1.3, 1.6) compared to less active adults. Thresholds were consistent across sex, body mass index, knee osteoarthritis status, and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results supported a physical activity minimum threshold of 45 total MV minutes\/week to promote improved or sustained high function for adults with lower\u2010extremity joint symptoms. This evidence\u2010based threshold is less rigorous than federal guidelines (\u2265150 MV\u2010bout minutes\/week) and provides an intermediate goal towards the federal guideline for adults with lower\u2010extremity symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23181","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T11:57:08Z","timestamp":1482926228000},"page":"475-483","source":"Crossref","is-referenced-by-count":66,"title":["Physical Activity Minimum Threshold Predicting Improved Function in Adults With Lower\u2010Extremity Symptoms"],"prefix":"10.1002","volume":"69","author":[{"given":"Dorothy D.","family":"Dunlop","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Song","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago 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