{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:34:55Z","timestamp":1770136495601,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["1H75DP001743\u201001"],"award-info":[{"award-number":["1H75DP001743\u201001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Objective<\/jats:title>Extensive studies on health\u2010related quality of life (HRQ<\/jats:styled-content>oL) in idiopathic inflammatory myopathies (IIM<\/jats:styled-content>s) are lacking. Our objective was to document HRQ<\/jats:styled-content>oL and to identify factors associated with a reduced HRQ<\/jats:styled-content>oL in patients with IIM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 1,715 patients (median age 49.9 years, 70% female, 87% white) who met probable or definite Bohan and Peter criteria or Griggs criteria for myositis were included from the Myovision registry. HRQ<\/jats:styled-content>oL was ascertained using the Short Form 12 (SF<\/jats:styled-content>\u201012) health survey questionnaire. HRQ<\/jats:styled-content>oL physical component summary (PCS<\/jats:styled-content>) and mental component summary (MCS<\/jats:styled-content>) scores in relation to different patient and disease characteristics were compared to scores from matched normative data from the US<\/jats:styled-content> general population and rheumatoid arthritis (RA<\/jats:styled-content>) patients. Bivariate and multiple linear regression analyses were performed to assess the association between HRQ<\/jats:styled-content>oL and patient and disease parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean SF<\/jats:styled-content>\u201012 summary scores were significantly lower in IIM<\/jats:styled-content> patients than in the normative and RA<\/jats:styled-content> populations. A diagnosis of inclusion body myositis, older age, patient\u2010reported negative effect of disease on work, presence of another co\u2010occurring autoimmune disease, polypharmacy, and IIM<\/jats:styled-content>\u2010associated lung disease and joint involvement were significantly associated with lower PCS<\/jats:styled-content> scores. Lower MCS<\/jats:styled-content> scores were associated with joint involvement and a negative effect of disease on work.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In this large study of patient\u2010reported outcomes in IIM<\/jats:styled-content>, an association was found between multiple disease characteristics and reduced HRQ<\/jats:styled-content>oL, mostly in the physical domain. In the US<\/jats:styled-content>, the HRQ<\/jats:styled-content>oL of IIM<\/jats:styled-content> patients was found to be lower than that of the general population and RA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23198","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T13:48:19Z","timestamp":1485265699000},"page":"1743-1750","source":"Crossref","is-referenced-by-count":43,"title":["Predictors of Reduced Health\u2010Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies"],"prefix":"10.1002","volume":"69","author":[{"given":"Michal","family":"Feldon","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payam Noroozi","family":"Farhadi","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermine I.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Itert","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"Goldberg","sequence":"additional","affiliation":[{"name":"The Myositis Association Alexandria Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Faiq","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Wilkerson","sequence":"additional","affiliation":[{"name":"Social and Scientific Systems Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M.","family":"Rose","sequence":"additional","affiliation":[{"name":"Social and Scientific Systems Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa G.","family":"Rider","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick W.","family":"Miller","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward H.","family":"Giannini","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600622132"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.045690"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2685-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.183863"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00009"},{"issue":"59","key":"e_1_2_7_9_1","first-page":"S32","article-title":"The impact of rheumatoid arthritis and treatment on patients\u2019 lives","volume":"28","author":"Strand V","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110899"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel218"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24477"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306071710"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.1.22"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh404"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq356"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160753"},{"key":"e_1_2_7_18_1","unstructured":"BenvenisteO RiderLG.213th ENMC international workshop: outcome measures and clinical trial readiness in idiopathic inflammatory myopathies; 2015 Sept 18\u201320; Heemskerk The Netherlands."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380504"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pubmed.a024606"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.8.862"},{"key":"e_1_2_7_25_1","volume-title":"User's manual for the SF\u201012v2 health survey","author":"Ware JE","year":"2010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10341"},{"key":"e_1_2_7_27_1","first-page":"1694","article-title":"Health status in systemic lupus erythematosus compared to rheumatoid arthritis and healthy controls","volume":"26","author":"Gilboe IM","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_28_1","first-page":"63","article-title":"Functional disability and end organ damage in patients with systemic lupus erythematosus (SLE), SLE and Sj\u00f6gren's syndrome (SS), and primary SS","volume":"25","author":"Sutcliffe N","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_29_1","first-page":"447","article-title":"A comparative study of outcome in myositis and other musculoskeletal disorders assessed using the Nottingham health profile","volume":"19","author":"Chung YL","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380907"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.12.1403"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph121113807"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(98)00411-0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-006-0025-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(99)00045-3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1206"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24562"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.173823"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr213"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000119"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.11.1262"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2825-x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3476-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22927"}],"container-title":["Arthritis Care & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:14:39Z","timestamp":1759418079000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/acr.23198"],"URL":"https:\/\/doi.org\/10.1002\/acr.23198","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}