{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:54:04Z","timestamp":1789952044273,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AR\u2010053503"],"award-info":[{"award-number":["P30\u2010AR\u2010053503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR\u201044684"],"award-info":[{"award-number":["R01\u2010AR\u201044684"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR\u2010062615\u201001A1"],"award-info":[{"award-number":["AR\u2010062615\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti\u2013NXP\u20102) antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Anti\u2013NXP\u20102 antibodies were assayed by immunoprecipitation using NXP\u20102 produced by in\u00a0vitro transcription\/translation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antibodies to NXP\u20102 were detected in 20 of the 178 patients (11%). Anti\u2013NXP\u20102 antibodies were associated with male sex (50% versus 25%; <jats:italic>P =<\/jats:italic> 0.02), dysphagia (74% versus 39%; <jats:italic>P<\/jats:italic> = 0.006), myalgia (89% versus 52%; <jats:italic>P<\/jats:italic> = 0.002), peripheral edema (35% versus 11%; <jats:italic>P<\/jats:italic> = 0.016), and calcinosis (37% versus 11%; <jats:italic>P<\/jats:italic> = 0.007). These patients were less likely to be clinically amyopathic (5% versus 23%; <jats:italic>P<\/jats:italic> = 0.08). Five of the 20 patients with anti\u2013NXP\u20102 antibodies (25%) had an associated internal malignancy. No other cutaneous characteristics were associated with anti\u2013NXP\u20102 antibodies, except a decreased frequency of Gottron's sign (44% versus 75%; <jats:italic>P<\/jats:italic> = 0.012) and a greater likelihood of having mild skin disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dermatomyositis patients with anti\u2013NXP\u20102 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23210","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T15:33:07Z","timestamp":1485531187000},"page":"1909-1914","source":"Crossref","is-referenced-by-count":109,"title":["Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients"],"prefix":"10.1002","volume":"69","author":[{"given":"Anna","family":"Rogers","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Chung","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Stanford, California, and Department of Veterans Affairs Palo Alto Health Care System Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Casciola\u2010Rosen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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